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- W4293254491 abstract "In cerebellar granule cells, δ subunit-containing GABA A receptors are found exclusively at extrasynaptic sites, but their subcellular distribution in other brain areas is poorly understood. We examined the anatomical localization and physiological activation of these receptors in adult mouse dentate gyrus granule cells. Immunocytochemistry revealed a high density of δ subunits in the molecular layer and a much lower density in the cell body layer. At the ultrastructural level, immunogold-labeled δ subunits were found at the edge of symmetric synapses on granule cell dendrites. Functional correlates of this perisynaptic localization were obtained by comparing inhibitory responses in δ subunit-deficient (δ-/-) and wild-type (wt) mice. In whole-cell recordings at 22°C, the weighted decay time constants (τ w ) of spontaneous IPSCs (sIPSCs) were significantly longer in wt mice but were similar at 34°C, reflecting the role of temperature-dependent GABA uptake in shaping sIPSC decay. IPSCs evoked by minimal stimulation (eIPSCs) near the somata had similar τ w in δ-/- and wt mice, but eIPSCs elicited from dendritic sites decayed significantly more slowly in wt mice, consistent with a higher density of δ subunit-containing receptors in the molecular layer. The τ w of dendritic eIPSCs of wt mice were shortened by ZnCl 2 (10 μ m ), reflecting the high Zn 2+ sensitivity of δ subunit-containing GABA A receptors, and were prolonged by the GAT-1 GABA transporter inhibitor NO711 (10 μ m ). Our results demonstrate a perisynaptic localization of δ subunit-containing GABA A receptors and indicate that these receptors can be activated by GABA overspill in the molecular layer." @default.
- W4293254491 created "2022-08-27" @default.
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- W4293254491 date "2003-11-19" @default.
- W4293254491 modified "2023-10-12" @default.
- W4293254491 title "Perisynaptic Localization of δ Subunit-Containing GABA<sub>A</sub>Receptors and Their Activation by GABA Spillover in the Mouse Dentate Gyrus" @default.
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- W4293254491 doi "https://doi.org/10.1523/jneurosci.23-33-10650.2003" @default.
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