Matches in SemOpenAlex for { <https://semopenalex.org/work/W4293695236> ?p ?o ?g. }
- W4293695236 endingPage "11" @default.
- W4293695236 startingPage "1" @default.
- W4293695236 abstract "Homoharringtonine- (HHT-) based HHT, aclarubicin, and cytarabine (HAA) induction regimen is the first-line therapy for nonelder acute myeloid leukemia (AML) patients in China. However, drug resistance is a new challenge, and little attention has been devoted to excavating resistant mechanisms. This study used the classic method to construct six HHT-resistant cell lines with a gradually increasing resistance index (RI) to discover HHT drug resistance mechanisms dynamically. After HHT resistance, the cell growth rate decreased, cell cycle delayed, and P-glycoprotein (p-gp, CD243) expression levels increased. Furthermore, we explored the changes in transcriptomics between HHT-sensitive and HHT-resistant cells using RNA-sequence. Through Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and hub gene analyses, we found that immune activity, especially G-protein coupled receptor (GPR) and related molecules, may mediate HHT resistance. Moreover, Calcitonin Receptor-Like (CALCRL) and G Protein Subunit Alpha I1 (GNAI1), which belong to GPRs, were stimulated in HHT-resistant cell strains in vitro and vivo, indicating that they may play a critical role in HHT resistance. In addition, these two genes have prognostic significance for AML patients. Taken together, we successfully constructed HHT-resistant cell lines with dynamic RIs and explored the resistance mechanisms, which will help identify new drugs for HHT-resistant AML patients." @default.
- W4293695236 created "2022-08-31" @default.
- W4293695236 creator A5002928156 @default.
- W4293695236 creator A5004760143 @default.
- W4293695236 creator A5008172804 @default.
- W4293695236 creator A5011862811 @default.
- W4293695236 creator A5014486696 @default.
- W4293695236 creator A5028634125 @default.
- W4293695236 creator A5031804038 @default.
- W4293695236 creator A5044809089 @default.
- W4293695236 creator A5059913267 @default.
- W4293695236 creator A5072500806 @default.
- W4293695236 creator A5076078835 @default.
- W4293695236 creator A5079738340 @default.
- W4293695236 creator A5080088656 @default.
- W4293695236 creator A5086581375 @default.
- W4293695236 date "2022-08-30" @default.
- W4293695236 modified "2023-10-14" @default.
- W4293695236 title "Characterization of the Newly Established Homoharringtonine- (HHT-) Resistant Cell Lines and Mechanisms of Resistance" @default.
- W4293695236 cites W1559420331 @default.
- W4293695236 cites W1982177033 @default.
- W4293695236 cites W2014573606 @default.
- W4293695236 cites W2026868469 @default.
- W4293695236 cites W2029912515 @default.
- W4293695236 cites W2063441242 @default.
- W4293695236 cites W2079025304 @default.
- W4293695236 cites W2090675458 @default.
- W4293695236 cites W2098791934 @default.
- W4293695236 cites W2102780770 @default.
- W4293695236 cites W2103912979 @default.
- W4293695236 cites W2109014958 @default.
- W4293695236 cites W2112797872 @default.
- W4293695236 cites W2124110638 @default.
- W4293695236 cites W2124284252 @default.
- W4293695236 cites W2154626333 @default.
- W4293695236 cites W2159363584 @default.
- W4293695236 cites W2301429255 @default.
- W4293695236 cites W2472831548 @default.
- W4293695236 cites W2507856777 @default.
- W4293695236 cites W2509517672 @default.
- W4293695236 cites W2537623931 @default.
- W4293695236 cites W2590604244 @default.
- W4293695236 cites W2799434965 @default.
- W4293695236 cites W2802089531 @default.
- W4293695236 cites W2915860404 @default.
- W4293695236 cites W2920536746 @default.
- W4293695236 cites W2948545594 @default.
- W4293695236 cites W2950764390 @default.
- W4293695236 cites W2952863579 @default.
- W4293695236 cites W2969548922 @default.
- W4293695236 cites W2990611267 @default.
- W4293695236 cites W3100513934 @default.
- W4293695236 cites W3207747818 @default.
- W4293695236 cites W4287025205 @default.
- W4293695236 doi "https://doi.org/10.1155/2022/2813938" @default.
- W4293695236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36081671" @default.
- W4293695236 hasPublicationYear "2022" @default.
- W4293695236 type Work @default.
- W4293695236 citedByCount "0" @default.
- W4293695236 crossrefType "journal-article" @default.
- W4293695236 hasAuthorship W4293695236A5002928156 @default.
- W4293695236 hasAuthorship W4293695236A5004760143 @default.
- W4293695236 hasAuthorship W4293695236A5008172804 @default.
- W4293695236 hasAuthorship W4293695236A5011862811 @default.
- W4293695236 hasAuthorship W4293695236A5014486696 @default.
- W4293695236 hasAuthorship W4293695236A5028634125 @default.
- W4293695236 hasAuthorship W4293695236A5031804038 @default.
- W4293695236 hasAuthorship W4293695236A5044809089 @default.
- W4293695236 hasAuthorship W4293695236A5059913267 @default.
- W4293695236 hasAuthorship W4293695236A5072500806 @default.
- W4293695236 hasAuthorship W4293695236A5076078835 @default.
- W4293695236 hasAuthorship W4293695236A5079738340 @default.
- W4293695236 hasAuthorship W4293695236A5080088656 @default.
- W4293695236 hasAuthorship W4293695236A5086581375 @default.
- W4293695236 hasBestOaLocation W42936952361 @default.
- W4293695236 hasConcept C104317684 @default.
- W4293695236 hasConcept C114851261 @default.
- W4293695236 hasConcept C150194340 @default.
- W4293695236 hasConcept C152724338 @default.
- W4293695236 hasConcept C162317418 @default.
- W4293695236 hasConcept C203014093 @default.
- W4293695236 hasConcept C2778041864 @default.
- W4293695236 hasConcept C2778729363 @default.
- W4293695236 hasConcept C2910157418 @default.
- W4293695236 hasConcept C502942594 @default.
- W4293695236 hasConcept C54355233 @default.
- W4293695236 hasConcept C60644358 @default.
- W4293695236 hasConcept C71924100 @default.
- W4293695236 hasConcept C86803240 @default.
- W4293695236 hasConcept C98274493 @default.
- W4293695236 hasConceptScore W4293695236C104317684 @default.
- W4293695236 hasConceptScore W4293695236C114851261 @default.
- W4293695236 hasConceptScore W4293695236C150194340 @default.
- W4293695236 hasConceptScore W4293695236C152724338 @default.
- W4293695236 hasConceptScore W4293695236C162317418 @default.
- W4293695236 hasConceptScore W4293695236C203014093 @default.
- W4293695236 hasConceptScore W4293695236C2778041864 @default.
- W4293695236 hasConceptScore W4293695236C2778729363 @default.