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- W4297018276 abstract "Abstract Cancer‐derived exosomes are involved in the development of cancer cachexia. Carnosol, which exhibited ameliorating effects on cancer cachexia of C26 tumour‐bearing mice in our previous study, alleviated atrophy of C2C12 myotubes induced by exosomes of C26 tumour cells in the present study. MiR‐183‐5p was found to be rich in C26 cells and C26 exosomes, and miR‐183‐5p mimic could directly induce atrophy of C2C12 myotubes. Carnosol at 5 to 20 μM could dose‐dependently ameliorate the myotube atrophy induced by miR‐183‐5p. Four and a half LIM domain protein 1 (FHL1) was shown to be the direct target of miR‐183‐5p. Increase in myostatin, p‐Smad3, MuRF‐1, Atrogin‐1, HIF‐1α and p‐STAT3 and decrease in mitochondrial respiration were also induced by miR‐183‐5p mimic in C2C12 myotubes. Carnosol could not affect the decrease in FHL‐1 and the activation of STAT3 pathway but could significantly alleviate the increase in myostatin, p‐Smad3, MuRF‐1, Atrogin‐1 and the decrease in mitochondrial respiration induced by miR‐183‐5p. The protective effects of carnosol on myotubes against atrophy of C2C12 myotubes induced by miR‐183‐5p, based on both its inhibiting effects on MuRF‐1 and Atrogin‐1‐mediated protein degradation and its ability of keeping the mitochondrial respiration, might contribute to its ameliorating effects on cancer cachexia." @default.
- W4297018276 created "2022-09-25" @default.
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- W4297018276 date "2022-10-05" @default.
- W4297018276 modified "2023-09-26" @default.
- W4297018276 title "Carnosol attenuated atrophy of C2C12 myotubes induced by tumour‐derived exosomal miR‐183‐5p through inhibiting Smad3 pathway activation and keeping mitochondrial respiration" @default.
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- W4297018276 doi "https://doi.org/10.1111/bcpt.13795" @default.
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