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- W4299377465 abstract "Abstract A novel flow-through design for a calcium ion-selective liquid membrane and half-cell is proposed. The membrane is based on a neutral carrier for calcium and has the same quantitative chemical composition as that used in most commercial analyzers for ionized calcium (iCa2+). The membrane and half-cell follow the specifications in the Stage 1, Draft 4 document for a Reference Method for iCa2+ of the IFCC Expert Panel on pH, Blood Gases, and Electrolytes. Measurements of iCa2+ in serum with this cell confirm prior observations that protein adsorption on the membrane surface causes a rapid but reversible shift in the cell calibration signal and possible systematic errors in the measurement of iCa2+ in serum. When the protein adsorption phenomenon is maintained at equilibrium during calibrations and sample measurements, the new cell can be used to reproducibly assign iCa2+ concentrations to serum pools. These calibrated pools may then be used as reference materials and to resolve the biases known to exist among commercial iCa2+ analyzers." @default.
- W4299377465 created "2022-10-02" @default.
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- W4299377465 date "1992-07-01" @default.
- W4299377465 modified "2023-10-18" @default.
- W4299377465 title "Design and Preliminary Performance Characteristics of a Newly Proposed Reference Cell for Ionized Calcium in Serum" @default.
- W4299377465 doi "https://doi.org/10.1093/clinchem/38.7.1332" @default.
- W4299377465 hasPublicationYear "1992" @default.
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