FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308309635> ?p ?o ?g. }

• W4308309635 endingPage "112060" @default.
• W4308309635 startingPage "112060" @default.
• W4308309635 abstract "Antioxidant activity toward H2O2, anion radical superoxide, hydroxyl and DPPH (2,2-diphenyl-1-picrylhydrazyl) of two manganese complexes [Mn(III)(bpa)2]Cl.H2O (1) and [(Cl)Mn(μ-hbpclnol)(μ-bpclnol)Mn](ClO4).3H2O (2) (hbpa = (2-hydroxybenzyl-2-pyridylmethyl)amine and h2bpclnol = (N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)[(3-chloro)(2-hydroxy)]propylamine) are presented. X-ray diffraction studies were performed for complex (1). Both complexes presented similar or better activities than reference complex [Mn(salen)Cl], when the interaction between them and ROS (H2O2, O2•- and •OH), was monitored, by EPR (Electron Paramagnetic Resonance), in PBS, DMSO and water. The antioxidant activity rank of complexes toward •OH, generated by Fenton reaction and monitored by EPR, is (2) > (1) > [Mn(salen)Cl], in water (0.1% of DMSO for each complex), with the values of the IC50 of 7.2 (±1.6), 15.5 (±1.8) and 29.1 (±2.01) μM respectively. EPR data presented herein suggest that complex (2) presents the better scavenging activity toward hydroxyl, being in good agreement with TBARS assay results, in which complex (2) presented the best inhibitory activity toward lipid peroxidation, employing Swiss mice liver homogenate tissue model. IC50 values obtained from the interaction between these complexes and hydroxyl, using TBARS method, were: 0.88 (± 0.029); 0.73 (± 0.01) and 42.7 (± 3.5) nM, respectively for (1), (2) and [Mn(salen)Cl]. Complexes (1) and (2) are regulating the lipid homeostasis, protecting the tissue from the lipid peroxidation, in nanomolar scale, motivating in vivo studies. Redox properties and radical scavenging activity of complexes toward DPPH are non-linear and solvent dependent. Furthermore, the monitoring of antioxidant activity probed by EPR could be a fair and appropriate study to guide more advanced investigations." @default.
• W4308309635 created "2022-11-10" @default.
• W4308309635 creator A5009686763 @default.
• W4308309635 creator A5011395820 @default.
• W4308309635 creator A5017658612 @default.
• W4308309635 creator A5019553500 @default.
• W4308309635 creator A5070937553 @default.
• W4308309635 creator A5072550761 @default.
• W4308309635 creator A5088571754 @default.
• W4308309635 creator A5091150009 @default.
• W4308309635 date "2023-02-01" @default.
• W4308309635 modified "2023-09-29" @default.
• W4308309635 title "Scavenging of reactive species probed by EPR and ex-vivo nanomolar reduction of lipid peroxidation of manganese complexes" @default.
• W4308309635 cites W1759768304 @default.
• W4308309635 cites W1967244854 @default.
• W4308309635 cites W1969360633 @default.
• W4308309635 cites W1987096917 @default.
• W4308309635 cites W2000887216 @default.
• W4308309635 cites W2012796644 @default.
• W4308309635 cites W2018076136 @default.
• W4308309635 cites W2021033806 @default.
• W4308309635 cites W2024500470 @default.
• W4308309635 cites W2060137054 @default.
• W4308309635 cites W2065304522 @default.
• W4308309635 cites W2066784502 @default.
• W4308309635 cites W2089893465 @default.
• W4308309635 cites W2090213901 @default.
• W4308309635 cites W2131350133 @default.
• W4308309635 cites W2161295112 @default.
• W4308309635 cites W2285749559 @default.
• W4308309635 cites W2474379020 @default.
• W4308309635 cites W2552468098 @default.
• W4308309635 cites W2787535179 @default.
• W4308309635 cites W2802324910 @default.
• W4308309635 cites W2899666631 @default.
• W4308309635 cites W2916145834 @default.
• W4308309635 cites W2944565805 @default.
• W4308309635 cites W2959068619 @default.
• W4308309635 cites W2992755259 @default.
• W4308309635 cites W3034112560 @default.
• W4308309635 cites W3047666959 @default.
• W4308309635 cites W3092272026 @default.
• W4308309635 cites W3136633260 @default.
• W4308309635 cites W3168180419 @default.
• W4308309635 cites W3175126077 @default.
• W4308309635 cites W3202303572 @default.
• W4308309635 cites W4206899503 @default.
• W4308309635 cites W4225688895 @default.
• W4308309635 doi "https://doi.org/10.1016/j.jinorgbio.2022.112060" @default.
• W4308309635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36402588" @default.
• W4308309635 hasPublicationYear "2023" @default.
• W4308309635 type Work @default.
• W4308309635 citedByCount "2" @default.
• W4308309635 countsByYear W43083096352023 @default.
• W4308309635 crossrefType "journal-article" @default.
• W4308309635 hasAuthorship W4308309635A5009686763 @default.
• W4308309635 hasAuthorship W4308309635A5011395820 @default.
• W4308309635 hasAuthorship W4308309635A5017658612 @default.
• W4308309635 hasAuthorship W4308309635A5019553500 @default.
• W4308309635 hasAuthorship W4308309635A5070937553 @default.
• W4308309635 hasAuthorship W4308309635A5072550761 @default.
• W4308309635 hasAuthorship W4308309635A5088571754 @default.
• W4308309635 hasAuthorship W4308309635A5091150009 @default.
• W4308309635 hasConcept C121332964 @default.
• W4308309635 hasConcept C13965031 @default.
• W4308309635 hasConcept C155647269 @default.
• W4308309635 hasConcept C178790620 @default.
• W4308309635 hasConcept C185592680 @default.
• W4308309635 hasConcept C187961010 @default.
• W4308309635 hasConcept C2776778087 @default.
• W4308309635 hasConcept C2777352226 @default.
• W4308309635 hasConcept C2778004101 @default.
• W4308309635 hasConcept C2780829032 @default.
• W4308309635 hasConcept C2781401929 @default.
• W4308309635 hasConcept C46141821 @default.
• W4308309635 hasConcept C528890316 @default.
• W4308309635 hasConcept C71240020 @default.
• W4308309635 hasConceptScore W4308309635C121332964 @default.
• W4308309635 hasConceptScore W4308309635C13965031 @default.
• W4308309635 hasConceptScore W4308309635C155647269 @default.
• W4308309635 hasConceptScore W4308309635C178790620 @default.
• W4308309635 hasConceptScore W4308309635C185592680 @default.
• W4308309635 hasConceptScore W4308309635C187961010 @default.
• W4308309635 hasConceptScore W4308309635C2776778087 @default.
• W4308309635 hasConceptScore W4308309635C2777352226 @default.
• W4308309635 hasConceptScore W4308309635C2778004101 @default.
• W4308309635 hasConceptScore W4308309635C2780829032 @default.
• W4308309635 hasConceptScore W4308309635C2781401929 @default.
• W4308309635 hasConceptScore W4308309635C46141821 @default.
• W4308309635 hasConceptScore W4308309635C528890316 @default.
• W4308309635 hasConceptScore W4308309635C71240020 @default.
• W4308309635 hasFunder F4320321091 @default.
• W4308309635 hasLocation W43083096351 @default.
• W4308309635 hasLocation W43083096352 @default.
• W4308309635 hasOpenAccess W4308309635 @default.
• W4308309635 hasPrimaryLocation W43083096351 @default.
• W4308309635 hasRelatedWork W2091645862 @default.
• W4308309635 hasRelatedWork W2102537907 @default.

• next