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- W4309506510 endingPage "422" @default.
- W4309506510 startingPage "409" @default.
- W4309506510 abstract "The neural pathways in which the brain regulates the cardiovascular system is via sympathetic and parasympathetic control of the heart and sympathetic control of the systemic vasculature. Various cortical and sub-cortical sites are involved, but how these critical brain regions for cardiovascular control are altered in healthy aging and other risk conditions that may contribute to cardiovascular disease is uncertain.Here we review the functional and structural brain changes in healthy aging, hypertension, and atrial fibrillation - noting their potential influence on the autonomic nervous system and hence on cardiovascular control.Evidence suggests that aging, hypertension, and atrial fibrillation are each associated with functional and structural changes in specific areas of the central nervous system involved in autonomic control. Increased muscle sympathetic nerve activity (MSNA) and significant alterations in the brain regions involved in the default mode network are commonly reported in aging, hypertension, and atrial fibrillation.Further studies using functional and structural magnetic resonance imaging (MRI) coupled with autonomic nerve activity in healthy aging, hypertension, and atrial fibrillation promise to reveal the underlying brain circuitry modulating the abnormal sympathetic nerve activity in these conditions. This understanding will guide future therapies to rectify dysregulation of autonomic and cardiovascular control by the brain." @default.
- W4309506510 created "2022-11-28" @default.
- W4309506510 creator A5027285137 @default.
- W4309506510 creator A5037855932 @default.
- W4309506510 creator A5076911397 @default.
- W4309506510 date "2022-11-21" @default.
- W4309506510 modified "2023-10-01" @default.
- W4309506510 title "Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation" @default.
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