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• W4309659519 startingPage "536" @default.
• W4309659519 abstract "Some patients unexpectedly display an unfavorable cognitive course after epilepsy surgery subsequent to any direct cognitive sequelae of the surgical treatment. Therefore, we conducted in-depth neuropathological examinations of resective specimens from corresponding patients to provide insights as to the underlying disease processes.In this study, cases with significant cognitive deterioration following a previous postoperative assessment were extracted from the neuropsychological database of a longstanding epilepsy surgical program. An extensive reanalysis of available specimens was performed using current, state-of-the-art neuropathological examinations. Patients without cognitive deterioration but matched in regard to basic pathologies served as controls.Among the 355 operated patients who had undergone more than one postoperative neuropsychological examination, 30 (8%) showed significant cognitive decline in the period after surgery. Of the 24 patients with available specimens, 71% displayed further neuropathological changes in addition to the typical spectrum (ie, hippocampal sclerosis, focal cortical dysplasias, vascular lesions, and low-grade tumors), indicating (1) a secondary, putatively epilepsy-independent neurodegenerative disease process; (2) limbic inflammation; or (3) the enigmatic pathology pattern of hippocampal gliosis without segmental neurodegeneration. In the controls, the matched individual principal epilepsy-associated pathologies were not found in combination with the secondary pathology patterns of the study group.Our findings indicate that patients who unexpectedly displayed unfavorable cognitive development beyond any direct surgical effects show rare and very particular pathogenetic causes or parallel, presumably independent, neurodegenerative alterations. A multicenter collection of such cases would be appreciated to discern presurgical biomarkers that help with surgical decision-making. ANN NEUROL 2023;93:536-550." @default.
• W4309659519 created "2022-11-29" @default.
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• W4309659519 date "2022-12-05" @default.
• W4309659519 modified "2023-10-07" @default.
• W4309659519 title "Neuropathological Insights into Unexpected Cognitive Decline in Epilepsy" @default.
• W4309659519 cites W1567279120 @default.
• W4309659519 cites W1618554272 @default.
• W4309659519 cites W1837238719 @default.
• W4309659519 cites W1878470469 @default.
• W4309659519 cites W1905249642 @default.
• W4309659519 cites W1964443484 @default.
• W4309659519 cites W1975940030 @default.
• W4309659519 cites W1983100194 @default.
• W4309659519 cites W1983883744 @default.
• W4309659519 cites W2000215974 @default.
• W4309659519 cites W2001490949 @default.
• W4309659519 cites W2010622342 @default.
• W4309659519 cites W2015490916 @default.
• W4309659519 cites W2015513895 @default.
• W4309659519 cites W2023545149 @default.
• W4309659519 cites W2026322049 @default.
• W4309659519 cites W2040822099 @default.
• W4309659519 cites W2047827560 @default.
• W4309659519 cites W2078056880 @default.
• W4309659519 cites W2078759460 @default.
• W4309659519 cites W2078947806 @default.
• W4309659519 cites W2079796269 @default.
• W4309659519 cites W2082471359 @default.
• W4309659519 cites W2091025602 @default.
• W4309659519 cites W2095422335 @default.
• W4309659519 cites W2105727230 @default.
• W4309659519 cites W2128008503 @default.
• W4309659519 cites W2128228199 @default.
• W4309659519 cites W2135894834 @default.
• W4309659519 cites W2140341262 @default.
• W4309659519 cites W2140479721 @default.
• W4309659519 cites W2141649584 @default.
• W4309659519 cites W2141944335 @default.
• W4309659519 cites W2151280892 @default.
• W4309659519 cites W2159112951 @default.
• W4309659519 cites W2160537062 @default.
• W4309659519 cites W2161524679 @default.
• W4309659519 cites W2165093990 @default.
• W4309659519 cites W2167495956 @default.
• W4309659519 cites W2167993924 @default.
• W4309659519 cites W2280783985 @default.
• W4309659519 cites W2281902806 @default.
• W4309659519 cites W2317495993 @default.
• W4309659519 cites W2440417904 @default.
• W4309659519 cites W2513581974 @default.
• W4309659519 cites W2553974788 @default.
• W4309659519 cites W2556060167 @default.
• W4309659519 cites W2571871603 @default.
• W4309659519 cites W2604552217 @default.
• W4309659519 cites W2743499986 @default.
• W4309659519 cites W2753558942 @default.
• W4309659519 cites W2761129192 @default.
• W4309659519 cites W2766424950 @default.
• W4309659519 cites W2766867032 @default.
• W4309659519 cites W2774765607 @default.
• W4309659519 cites W2779150671 @default.
• W4309659519 cites W2792435683 @default.
• W4309659519 cites W2890071385 @default.
• W4309659519 cites W2894341297 @default.
• W4309659519 cites W2921574790 @default.
• W4309659519 cites W2922230197 @default.
• W4309659519 cites W2973212062 @default.
• W4309659519 cites W3006919270 @default.
• W4309659519 cites W3011920377 @default.
• W4309659519 cites W3036494323 @default.
• W4309659519 cites W3081375161 @default.
• W4309659519 cites W3092269026 @default.
• W4309659519 cites W3097548998 @default.
• W4309659519 cites W3111331564 @default.
• W4309659519 cites W3117399034 @default.
• W4309659519 cites W3157498260 @default.
• W4309659519 cites W3158900889 @default.
• W4309659519 cites W3180306493 @default.
• W4309659519 cites W3204219466 @default.
• W4309659519 cites W3216615419 @default.
• W4309659519 cites W4235813114 @default.
• W4309659519 cites W4237037994 @default.
• W4309659519 cites W4249569300 @default.
• W4309659519 cites W783768624 @default.
• W4309659519 doi "https://doi.org/10.1002/ana.26557" @default.
• W4309659519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36411525" @default.
• W4309659519 hasPublicationYear "2022" @default.
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