Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310447761> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4310447761 endingPage "20" @default.
- W4310447761 startingPage "416" @default.
- W4310447761 abstract "BACKGROUND: Formation of tumour mass is one symptom of osteosarcoma development. Caffeic acid has been known to provide effective treatment but has less side effect for some cancer therapy. Studies reported that caffeic acid might promote apoptosis in MG-63 osteosarcoma cells, however, the effect of caffeic acid treatment in preventing tumour mass formation has not been well elucidated, especially in MG-63 cells-induced nude mice in vivo.METHODS: MG-63 cells were pre-treated with 0, 1, or 10 µg/mL caffeic acid, and 6 hours after pre-treatment, MG-63 cells were injected into subcutaneous space of mice to induce osteosarcoma. Another model was also created by subcutaneously injecting MG-63 cells to the back of mice, and after 48 days, the visible tumour mass was injected intra-tumour with 0 or 10 µg/mL caffeic acid every 7 days for 6 times. After 90 days, mice were anaesthetised, and the nodule pictures were taken for observation and measurement. RESULTS: In pre-treated MG-63 cells-induced mice, volumes of the mass decreased in reverse with the dose of caffeic acid given. Ten µg/mL caffeic acid pre-treatment was able to significantly lower the mass volume compared to the untreated (p<0.05). Meanwhile, the intra-tumour treatment of 10 µg/mL caffeic acid, even though not significant, was able to inhibit tumour mass formation.CONCLUSION: Results of caffeic acid pre-treatment and caffeic acid treatment in tumour mass of mice show that caffeic acid is able to inhibit the MG-63 cells formation. This suggests that caffeic acid can be a potential anti-cancer agent.KEYWORDS: caffeic acid, osteosarcoma, MG-63 cells, tumour mass" @default.
- W4310447761 created "2022-12-10" @default.
- W4310447761 creator A5040275418 @default.
- W4310447761 creator A5062947620 @default.
- W4310447761 creator A5074157341 @default.
- W4310447761 creator A5087508445 @default.
- W4310447761 creator A5089649516 @default.
- W4310447761 date "2022-12-01" @default.
- W4310447761 modified "2023-09-26" @default.
- W4310447761 title "Caffeic Acid Inhibits Tumour Mass Formation in MG-63 Cells-induced Nude Mice" @default.
- W4310447761 doi "https://doi.org/10.18585/inabj.v14i4.2078" @default.
- W4310447761 hasPublicationYear "2022" @default.
- W4310447761 type Work @default.
- W4310447761 citedByCount "0" @default.
- W4310447761 crossrefType "journal-article" @default.
- W4310447761 hasAuthorship W4310447761A5040275418 @default.
- W4310447761 hasAuthorship W4310447761A5062947620 @default.
- W4310447761 hasAuthorship W4310447761A5074157341 @default.
- W4310447761 hasAuthorship W4310447761A5087508445 @default.
- W4310447761 hasAuthorship W4310447761A5089649516 @default.
- W4310447761 hasBestOaLocation W43104477611 @default.
- W4310447761 hasConcept C150903083 @default.
- W4310447761 hasConcept C153911025 @default.
- W4310447761 hasConcept C185592680 @default.
- W4310447761 hasConcept C190283241 @default.
- W4310447761 hasConcept C207001950 @default.
- W4310447761 hasConcept C2777760704 @default.
- W4310447761 hasConcept C2778004101 @default.
- W4310447761 hasConcept C2778224086 @default.
- W4310447761 hasConcept C502942594 @default.
- W4310447761 hasConcept C55493867 @default.
- W4310447761 hasConcept C71924100 @default.
- W4310447761 hasConcept C86803240 @default.
- W4310447761 hasConcept C98274493 @default.
- W4310447761 hasConceptScore W4310447761C150903083 @default.
- W4310447761 hasConceptScore W4310447761C153911025 @default.
- W4310447761 hasConceptScore W4310447761C185592680 @default.
- W4310447761 hasConceptScore W4310447761C190283241 @default.
- W4310447761 hasConceptScore W4310447761C207001950 @default.
- W4310447761 hasConceptScore W4310447761C2777760704 @default.
- W4310447761 hasConceptScore W4310447761C2778004101 @default.
- W4310447761 hasConceptScore W4310447761C2778224086 @default.
- W4310447761 hasConceptScore W4310447761C502942594 @default.
- W4310447761 hasConceptScore W4310447761C55493867 @default.
- W4310447761 hasConceptScore W4310447761C71924100 @default.
- W4310447761 hasConceptScore W4310447761C86803240 @default.
- W4310447761 hasConceptScore W4310447761C98274493 @default.
- W4310447761 hasIssue "4" @default.
- W4310447761 hasLocation W43104477611 @default.
- W4310447761 hasOpenAccess W4310447761 @default.
- W4310447761 hasPrimaryLocation W43104477611 @default.
- W4310447761 hasRelatedWork W1966228522 @default.
- W4310447761 hasRelatedWork W2056253602 @default.
- W4310447761 hasRelatedWork W2351101938 @default.
- W4310447761 hasRelatedWork W2358929219 @default.
- W4310447761 hasRelatedWork W2375068014 @default.
- W4310447761 hasRelatedWork W2389166408 @default.
- W4310447761 hasRelatedWork W2389204926 @default.
- W4310447761 hasRelatedWork W2431361778 @default.
- W4310447761 hasRelatedWork W2773986280 @default.
- W4310447761 hasRelatedWork W3147446945 @default.
- W4310447761 hasVolume "14" @default.
- W4310447761 isParatext "false" @default.
- W4310447761 isRetracted "false" @default.
- W4310447761 workType "article" @default.