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• W4311582242 abstract "Abstract Excessive fat accumulation in the liver has become a major health threat worldwide. Unresolved fat deposition in the liver can go undetected until it develops into fatty liver disease, followed by steatohepatitis, fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Lipid deposition in the liver is governed by complex communication, primarily between metabolic organs. This can be mediated by hormones, organokines, and also, as has been more recently discovered, metabolites. Although how metabolites from peripheral organs affect the liver is well documented, the effect of metabolic players released from the liver during the development of fatty liver disease or associated comorbidities needs further attention. Here we focus on interorgan crosstalk based on metabolites released from the liver and how these molecules act as signaling molecules in peripheral tissues. Due to the liver’s specific role, we are covering lipid and bile mechanism-derived metabolites. We also discuss the high sucrose intake associated with uric acid release from the liver. Excessive fat deposition in the liver during fatty liver disease development reflects disrupted metabolic processes. As a response, the liver secretes a variety of signaling molecules as well as metabolites which act as a footprint of the metabolic disruption. In the coming years, the reciprocal exchange of metabolites between the liver and other metabolic organs will gain further importance and will help to better understand the development of fatty liver disease and associated diseases." @default.
• W4311582242 created "2022-12-27" @default.
• W4311582242 creator A5001535197 @default.
• W4311582242 creator A5001577497 @default.
• W4311582242 creator A5035715100 @default.
• W4311582242 creator A5055174616 @default.
• W4311582242 creator A5063169050 @default.
• W4311582242 date "2022-12-07" @default.
• W4311582242 modified "2023-10-09" @default.
• W4311582242 title "Liver-derived metabolites as signaling molecules in fatty liver disease" @default.
• W4311582242 cites W1514177613 @default.
• W4311582242 cites W1530661366 @default.
• W4311582242 cites W1532838319 @default.
• W4311582242 cites W1573642714 @default.
• W4311582242 cites W1599893459 @default.
• W4311582242 cites W1911520061 @default.
• W4311582242 cites W1947392633 @default.
• W4311582242 cites W1966641285 @default.
• W4311582242 cites W1969703390 @default.
• W4311582242 cites W1973409643 @default.
• W4311582242 cites W1974040328 @default.
• W4311582242 cites W1979523405 @default.
• W4311582242 cites W1985683101 @default.
• W4311582242 cites W1987586494 @default.
• W4311582242 cites W1990819179 @default.
• W4311582242 cites W1993458861 @default.
• W4311582242 cites W1995573327 @default.
• W4311582242 cites W1995687483 @default.
• W4311582242 cites W1996268130 @default.
• W4311582242 cites W2000963707 @default.
• W4311582242 cites W2002121467 @default.
• W4311582242 cites W2009772745 @default.
• W4311582242 cites W2013907285 @default.
• W4311582242 cites W2020275122 @default.
• W4311582242 cites W2023440163 @default.
• W4311582242 cites W2025470394 @default.
• W4311582242 cites W2029789532 @default.
• W4311582242 cites W2030901818 @default.
• W4311582242 cites W2033112320 @default.
• W4311582242 cites W2038013958 @default.
• W4311582242 cites W2038681065 @default.
• W4311582242 cites W2039222039 @default.
• W4311582242 cites W2039432238 @default.
• W4311582242 cites W2039768005 @default.
• W4311582242 cites W2039963918 @default.
• W4311582242 cites W2041451676 @default.
• W4311582242 cites W2041572943 @default.
• W4311582242 cites W2043896734 @default.
• W4311582242 cites W2044131015 @default.
• W4311582242 cites W2045152332 @default.
• W4311582242 cites W2046783680 @default.
• W4311582242 cites W2048184523 @default.
• W4311582242 cites W2051999166 @default.
• W4311582242 cites W2053302563 @default.
• W4311582242 cites W2053581007 @default.
• W4311582242 cites W2057039181 @default.
• W4311582242 cites W2065912402 @default.
• W4311582242 cites W2068458442 @default.
• W4311582242 cites W2070360049 @default.
• W4311582242 cites W2072362233 @default.
• W4311582242 cites W2073656642 @default.
• W4311582242 cites W2075331768 @default.
• W4311582242 cites W2076511407 @default.
• W4311582242 cites W2077936393 @default.
• W4311582242 cites W2079019214 @default.
• W4311582242 cites W2081028309 @default.
• W4311582242 cites W2081271380 @default.
• W4311582242 cites W2089353165 @default.
• W4311582242 cites W2090721334 @default.
• W4311582242 cites W2091064562 @default.
• W4311582242 cites W2091106363 @default.
• W4311582242 cites W2092412521 @default.
• W4311582242 cites W2095038001 @default.
• W4311582242 cites W2095717717 @default.
• W4311582242 cites W2096418655 @default.
• W4311582242 cites W2096615817 @default.
• W4311582242 cites W2098012175 @default.
• W4311582242 cites W2100198908 @default.
• W4311582242 cites W2104004584 @default.
• W4311582242 cites W2105270157 @default.
• W4311582242 cites W2106678312 @default.
• W4311582242 cites W2107481002 @default.
• W4311582242 cites W2107542389 @default.
• W4311582242 cites W2109100903 @default.
• W4311582242 cites W2109132990 @default.
• W4311582242 cites W2114815536 @default.
• W4311582242 cites W2116580211 @default.
• W4311582242 cites W2117413045 @default.
• W4311582242 cites W2122252892 @default.
• W4311582242 cites W2126838672 @default.
• W4311582242 cites W2127056938 @default.
• W4311582242 cites W2127926242 @default.
• W4311582242 cites W2128326754 @default.
• W4311582242 cites W2130404519 @default.
• W4311582242 cites W2131256997 @default.
• W4311582242 cites W2133151327 @default.
• W4311582242 cites W2133290655 @default.
• W4311582242 cites W2134897177 @default.
• W4311582242 cites W2139351004 @default.
• W4311582242 cites W2142336938 @default.

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