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- W4313015093 abstract "<b>Background:</b> COPD and bronchiectasis are heterogenous diseases; spirometry rarely identifies the site of pathology, while lung structure assessed by CT may poorly correlate with functional severity. <b>Aim:</b> To evaluate the utility of 19F-MRI of inhaled perfluoropropane (PFP) for regional functional assessment of pulmonary ventilation in a patient with COPD and mild bronchiectasis. <b>Methods:</b> 19F-MR ventilation images were acquired during static (breath-hold) and dynamic imaging (multiple wash-in breaths), using a 79% PFP/21% O2 gas mixture. Images were segmented to calculate the ventilation defect percentage (VDP) and co-registered with CT images previously segmented for percentage low-attenuation (PLA) regions. Regions of ventilation defect were compared using the Dice similarity coefficient, and with spirometry. <b>Results:</b> Patient images and spirometric values are shown in Figure 1. VDP (derived from 19F-MRI) was 43.3%; PLA (derived from CT) was 21.7%; overlap=38%. The flow-volume loop showed an obstructive pattern typical of airways collapse. <b>Conclusion:</b> Regions of ventilation impairment were revealed by 19F-MRI where only mild bronchiectasis was reported on CT, highlighting the potential to provide important information regarding lung function that is not apparent on CT or spirometry alone. This technique could be beneficial in planning individualised patient treatments, such as cancer treatments or lung volume reduction in patients with COPD." @default.
- W4313015093 created "2023-01-05" @default.
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- W4313015093 date "2022-09-04" @default.
- W4313015093 modified "2023-09-28" @default.
- W4313015093 title "Comparison of 19F-MRI, CT and spirometry in a patient with airways disease" @default.
- W4313015093 doi "https://doi.org/10.1183/13993003.congress-2022.4309" @default.
- W4313015093 hasPublicationYear "2022" @default.
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