Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313235216> ?p ?o ?g. }
- W4313235216 abstract "Asthma is a chronic airway inflammatory disease characterized by reversible airway obstruction and airway hyperreactivity to various environmental stimuli, leading to recurrent cough, dyspnea, and wheezing episodes. Regarding inflammatory mechanisms, type 2/eosinophilic inflammation along with activated mast cells is the major one; however, diverse mechanisms, including structural cells-derived and non-type 2/neutrophilic inflammations are involved, presenting heterogenous phenotypes. Although most asthmatic patients could be properly controlled by the guided treatment, patients with severe asthma (SA; classified as a treatment-refractory group) suffer from uncontrolled symptoms with frequent asthma exacerbations even on regular anti-inflammatory medications, raising needs for additional controllers, including biologics that target specific molecules found in asthmatic airway, and achieving the precision medicine for asthma. This review summarizes the immunologic basis of airway inflammatory mechanisms and current biologics for SA in order to address unmet needs for future targets." @default.
- W4313235216 created "2023-01-06" @default.
- W4313235216 creator A5033290246 @default.
- W4313235216 creator A5038852974 @default.
- W4313235216 creator A5070662112 @default.
- W4313235216 date "2022-01-01" @default.
- W4313235216 modified "2023-10-02" @default.
- W4313235216 title "Immunologic Basis of Type 2 Biologics for Severe Asthma" @default.
- W4313235216 cites W1520991027 @default.
- W4313235216 cites W1572269513 @default.
- W4313235216 cites W1581053690 @default.
- W4313235216 cites W1845407473 @default.
- W4313235216 cites W1949221250 @default.
- W4313235216 cites W1969815811 @default.
- W4313235216 cites W1984407952 @default.
- W4313235216 cites W1992158509 @default.
- W4313235216 cites W2006744847 @default.
- W4313235216 cites W2012501349 @default.
- W4313235216 cites W2013105339 @default.
- W4313235216 cites W2013664708 @default.
- W4313235216 cites W2021701428 @default.
- W4313235216 cites W2037883863 @default.
- W4313235216 cites W2038883847 @default.
- W4313235216 cites W2039930386 @default.
- W4313235216 cites W2049426078 @default.
- W4313235216 cites W2061435251 @default.
- W4313235216 cites W2065997245 @default.
- W4313235216 cites W2075699130 @default.
- W4313235216 cites W2077693876 @default.
- W4313235216 cites W2097676518 @default.
- W4313235216 cites W2104934425 @default.
- W4313235216 cites W2123257822 @default.
- W4313235216 cites W2149810044 @default.
- W4313235216 cites W2309688181 @default.
- W4313235216 cites W2416712717 @default.
- W4313235216 cites W2511120040 @default.
- W4313235216 cites W2515900781 @default.
- W4313235216 cites W2517035143 @default.
- W4313235216 cites W2534261386 @default.
- W4313235216 cites W2585010481 @default.
- W4313235216 cites W2606710770 @default.
- W4313235216 cites W2619633721 @default.
- W4313235216 cites W2619733315 @default.
- W4313235216 cites W2731159563 @default.
- W4313235216 cites W2743335049 @default.
- W4313235216 cites W2743498934 @default.
- W4313235216 cites W2752147785 @default.
- W4313235216 cites W2752584372 @default.
- W4313235216 cites W2752655957 @default.
- W4313235216 cites W2754857446 @default.
- W4313235216 cites W2757963532 @default.
- W4313235216 cites W2761557216 @default.
- W4313235216 cites W2774288322 @default.
- W4313235216 cites W2792366526 @default.
- W4313235216 cites W2799420115 @default.
- W4313235216 cites W2800851550 @default.
- W4313235216 cites W2803404900 @default.
- W4313235216 cites W2803625106 @default.
- W4313235216 cites W2803941918 @default.
- W4313235216 cites W2810559136 @default.
- W4313235216 cites W2883878201 @default.
- W4313235216 cites W2885242616 @default.
- W4313235216 cites W2885771487 @default.
- W4313235216 cites W2888063502 @default.
- W4313235216 cites W2888124602 @default.
- W4313235216 cites W2896299453 @default.
- W4313235216 cites W2898310887 @default.
- W4313235216 cites W2899629727 @default.
- W4313235216 cites W2899859300 @default.
- W4313235216 cites W2903790709 @default.
- W4313235216 cites W2904556803 @default.
- W4313235216 cites W2907720247 @default.
- W4313235216 cites W2912667912 @default.
- W4313235216 cites W2941234997 @default.
- W4313235216 cites W2945280773 @default.
- W4313235216 cites W2955025518 @default.
- W4313235216 cites W2963134224 @default.
- W4313235216 cites W2974946068 @default.
- W4313235216 cites W2975181559 @default.
- W4313235216 cites W2987323970 @default.
- W4313235216 cites W2990603866 @default.
- W4313235216 cites W3005931313 @default.
- W4313235216 cites W3009509122 @default.
- W4313235216 cites W3029640415 @default.
- W4313235216 cites W3035290143 @default.
- W4313235216 cites W3077822952 @default.
- W4313235216 cites W3083879215 @default.
- W4313235216 cites W3085273970 @default.
- W4313235216 cites W3097429042 @default.
- W4313235216 cites W3110665800 @default.
- W4313235216 cites W3118418983 @default.
- W4313235216 cites W3121128244 @default.
- W4313235216 cites W3129160632 @default.
- W4313235216 cites W3133204522 @default.
- W4313235216 cites W3135674103 @default.
- W4313235216 cites W3152867209 @default.
- W4313235216 cites W3162024685 @default.
- W4313235216 cites W3171518808 @default.
- W4313235216 cites W3173990964 @default.
- W4313235216 cites W3184473427 @default.