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- W4313310001 abstract "Abstract Pooled IgG immunoglobulin heavy chains from five avian species were subjected to Edman degradation on an automated protein sequencer. Over 50% of each preparation was “unblocked” and suitable for automated sequencing. A single amino acid was present in greater than 90% of the positions studied. Analysis to position 24 or beyond showed unequivocally that these proteins belong in the VHIII subgroup. The sequence studies allowed the derivation of a prototype avian sequence for the VHIII subgroup. When this avian prototype was compared with the mammalian prototype VHIII sequence, a high degree of sequence conservation was apparent. Such conservation, considered with the presence of phylogenetically associated residues in both the avian and mammalian proteins, strongly suggests that only limited numbers of germ line genes code for proteins of the VHIII subgroup." @default.
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- W4313310001 date "1974-09-01" @default.
- W4313310001 modified "2023-09-28" @default.
- W4313310001 title "The VHIII Subgroup of Immunoglobulin Heavy Chains: Phylogenetically Associated Residues in Several Avian Species" @default.
- W4313310001 doi "https://doi.org/10.4049/jimmunol.113.3.954" @default.
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