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- W4313344540 abstract "Abstract It is generally accepted that immunologically naive T cells display a very restricted cytokine production profile consisting mainly of IL-2, which is used as an autocrine growth factor. Here we report that activated naive CD4+ T cells, of neonatal or adult origin, express very high levels of soluble lymphotoxin (LT) α (LTα3), as determined by ELISA, RNase protection assay, and intracytoplasmic staining. Besides LTα3 and IL-2, these cells also produce high levels of TNF-α together with significant amounts of IFN-γ and IL-13. Naive cells also express LTβ mRNA and the membrane form of LTα (LTαβ). On average, naive CD4+ T cells secrete four times more LTα3 than Th1-like cells, twice more than naive CD8+ T cells, and ten times more than B cells. Thus, naive T cells express a large spectrum of cytokines, mainly of the Th1 type, and the very high levels of LTα3/TNF-α that they release may play an hitherto unsuspected role in the early stage of T cell-dependent immune responses." @default.
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- W4313344540 date "1999-04-01" @default.
- W4313344540 modified "2023-10-14" @default.
- W4313344540 title "Naive Human CD4+ T Cells Are a Major Source of Lymphotoxin α" @default.
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- W4313344540 doi "https://doi.org/10.4049/jimmunol.162.7.3790" @default.
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