Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313366072> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313366072 endingPage "182.21" @default.
- W4313366072 startingPage "182.21" @default.
- W4313366072 abstract "Abstract Systematic Lupus Erythematosus (SLE) is an autoimmune syndrome of unclear etiology. While T and B cell abnormalities contribute to disease pathogenesis, recent work suggests that inflammatory M1-like macrophages also play a role. Previous work showed that the TLR2/1 agonist PAM3CSK4 (PAM3) could stimulate normal human monocytes to preferentially differentiate into immunosuppressive M2-like rather than inflammatory M1-like macrophages. This raised the possibility of PAM3 being used to normalize the M1:M2 ratio in SLE. Consistent with that possibility, monocytes from lupus patients differentiated into M2-like macrophages when treated with PAM3 in vitro. Furthermore, lupus-prone NZB x NZW F1 mice responded similarly to weekly PAM3 treatment. Normalization of the M2 macrophage frequency was associated with delayed disease progression, decreased autoantibody and inflammatory cytokine synthesis, reduced proteinuria and prolonged survival in NZB x NZW F1 mice. The ability of PAM3 to bias monocyte differentiation in favor of immunosuppressive macrophages may represent a novel approach to the therapy of SLE." @default.
- W4313366072 created "2023-01-06" @default.
- W4313366072 creator A5002584399 @default.
- W4313366072 creator A5010407321 @default.
- W4313366072 creator A5041521433 @default.
- W4313366072 creator A5043470455 @default.
- W4313366072 creator A5047205736 @default.
- W4313366072 creator A5053804951 @default.
- W4313366072 creator A5058816332 @default.
- W4313366072 date "2019-05-01" @default.
- W4313366072 modified "2023-09-30" @default.
- W4313366072 title "PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus" @default.
- W4313366072 doi "https://doi.org/10.4049/jimmunol.202.supp.182.21" @default.
- W4313366072 hasPublicationYear "2019" @default.
- W4313366072 type Work @default.
- W4313366072 citedByCount "0" @default.
- W4313366072 crossrefType "journal-article" @default.
- W4313366072 hasAuthorship W4313366072A5002584399 @default.
- W4313366072 hasAuthorship W4313366072A5010407321 @default.
- W4313366072 hasAuthorship W4313366072A5041521433 @default.
- W4313366072 hasAuthorship W4313366072A5043470455 @default.
- W4313366072 hasAuthorship W4313366072A5047205736 @default.
- W4313366072 hasAuthorship W4313366072A5053804951 @default.
- W4313366072 hasAuthorship W4313366072A5058816332 @default.
- W4313366072 hasConcept C126322002 @default.
- W4313366072 hasConcept C159654299 @default.
- W4313366072 hasConcept C163764329 @default.
- W4313366072 hasConcept C203014093 @default.
- W4313366072 hasConcept C2776070231 @default.
- W4313366072 hasConcept C2776912625 @default.
- W4313366072 hasConcept C2776914184 @default.
- W4313366072 hasConcept C2779075594 @default.
- W4313366072 hasConcept C2779134260 @default.
- W4313366072 hasConcept C2780942790 @default.
- W4313366072 hasConcept C2781184567 @default.
- W4313366072 hasConcept C2781236682 @default.
- W4313366072 hasConcept C71924100 @default.
- W4313366072 hasConceptScore W4313366072C126322002 @default.
- W4313366072 hasConceptScore W4313366072C159654299 @default.
- W4313366072 hasConceptScore W4313366072C163764329 @default.
- W4313366072 hasConceptScore W4313366072C203014093 @default.
- W4313366072 hasConceptScore W4313366072C2776070231 @default.
- W4313366072 hasConceptScore W4313366072C2776912625 @default.
- W4313366072 hasConceptScore W4313366072C2776914184 @default.
- W4313366072 hasConceptScore W4313366072C2779075594 @default.
- W4313366072 hasConceptScore W4313366072C2779134260 @default.
- W4313366072 hasConceptScore W4313366072C2780942790 @default.
- W4313366072 hasConceptScore W4313366072C2781184567 @default.
- W4313366072 hasConceptScore W4313366072C2781236682 @default.
- W4313366072 hasConceptScore W4313366072C71924100 @default.
- W4313366072 hasIssue "1_Supplement" @default.
- W4313366072 hasLocation W43133660721 @default.
- W4313366072 hasOpenAccess W4313366072 @default.
- W4313366072 hasPrimaryLocation W43133660721 @default.
- W4313366072 hasRelatedWork W1484311423 @default.
- W4313366072 hasRelatedWork W1924968745 @default.
- W4313366072 hasRelatedWork W2090245434 @default.
- W4313366072 hasRelatedWork W2093868050 @default.
- W4313366072 hasRelatedWork W2395197798 @default.
- W4313366072 hasRelatedWork W2742282730 @default.
- W4313366072 hasRelatedWork W3032623092 @default.
- W4313366072 hasRelatedWork W3143030268 @default.
- W4313366072 hasRelatedWork W4309888487 @default.
- W4313366072 hasRelatedWork W4313386619 @default.
- W4313366072 hasVolume "202" @default.
- W4313366072 isParatext "false" @default.
- W4313366072 isRetracted "false" @default.
- W4313366072 workType "article" @default.