Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313373488> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313373488 endingPage "160.22" @default.
- W4313373488 startingPage "160.22" @default.
- W4313373488 abstract "Abstract Background Dimethylfumarate (DMF) and ocrelizumab are two effective immunomodulators for multiple sclerosis but their mechanism of action involves different immune pathways. In this study we constructed immunomodulatory networks from cytokine and immunoprofiling data to evaluate the similarities and differences between these two disease modifying therapies in multiple sclerosis (MS). Methods Plasma and PBMCs from 16 and 13 MS patients were collected at baseline, 3 months and 6 months after treatment with DMF and ocrelizumab respectively. Cytokine analysis from plasma was performed with Olink assays and immunophenotyping was done by Cytof. Data were integrated with weighted correlation network analysis and highly interconnected modules were identified. Associations between modules and therapy was done with linear mixed effect models. Results DMF treatment was associated with a significant reduction of a module responsible for chemokine signaling pathways and cytokine-cytokine receptor interactions, whereas ocrelizumab treatment led to the increase of a module of soluble factors that are involved in tryptophan metabolism and foxp3 activation. DMF also reduced both T and B cell memory populations and ocrelizumab exerted its immunomodulatory effect by mostly reducing the frequency of memory B cells. Conclusions Our results suggest that DMF and ocrelizumab affect different immune networks to exert their effect in multiple sclerosis patients." @default.
- W4313373488 created "2023-01-06" @default.
- W4313373488 creator A5025501697 @default.
- W4313373488 creator A5033220689 @default.
- W4313373488 creator A5047139976 @default.
- W4313373488 creator A5054970583 @default.
- W4313373488 creator A5062473952 @default.
- W4313373488 creator A5075977363 @default.
- W4313373488 creator A5081181514 @default.
- W4313373488 date "2020-05-01" @default.
- W4313373488 modified "2023-09-25" @default.
- W4313373488 title "Immunomodulatory networks in multiple sclerosis" @default.
- W4313373488 doi "https://doi.org/10.4049/jimmunol.204.supp.160.22" @default.
- W4313373488 hasPublicationYear "2020" @default.
- W4313373488 type Work @default.
- W4313373488 citedByCount "0" @default.
- W4313373488 crossrefType "journal-article" @default.
- W4313373488 hasAuthorship W4313373488A5025501697 @default.
- W4313373488 hasAuthorship W4313373488A5033220689 @default.
- W4313373488 hasAuthorship W4313373488A5047139976 @default.
- W4313373488 hasAuthorship W4313373488A5054970583 @default.
- W4313373488 hasAuthorship W4313373488A5062473952 @default.
- W4313373488 hasAuthorship W4313373488A5075977363 @default.
- W4313373488 hasAuthorship W4313373488A5081181514 @default.
- W4313373488 hasConcept C13373296 @default.
- W4313373488 hasConcept C203014093 @default.
- W4313373488 hasConcept C2776036978 @default.
- W4313373488 hasConcept C2776819417 @default.
- W4313373488 hasConcept C2778690821 @default.
- W4313373488 hasConcept C2778843634 @default.
- W4313373488 hasConcept C2779338263 @default.
- W4313373488 hasConcept C2780640218 @default.
- W4313373488 hasConcept C2780653079 @default.
- W4313373488 hasConcept C71924100 @default.
- W4313373488 hasConcept C8891405 @default.
- W4313373488 hasConceptScore W4313373488C13373296 @default.
- W4313373488 hasConceptScore W4313373488C203014093 @default.
- W4313373488 hasConceptScore W4313373488C2776036978 @default.
- W4313373488 hasConceptScore W4313373488C2776819417 @default.
- W4313373488 hasConceptScore W4313373488C2778690821 @default.
- W4313373488 hasConceptScore W4313373488C2778843634 @default.
- W4313373488 hasConceptScore W4313373488C2779338263 @default.
- W4313373488 hasConceptScore W4313373488C2780640218 @default.
- W4313373488 hasConceptScore W4313373488C2780653079 @default.
- W4313373488 hasConceptScore W4313373488C71924100 @default.
- W4313373488 hasConceptScore W4313373488C8891405 @default.
- W4313373488 hasIssue "1_Supplement" @default.
- W4313373488 hasLocation W43133734881 @default.
- W4313373488 hasOpenAccess W4313373488 @default.
- W4313373488 hasPrimaryLocation W43133734881 @default.
- W4313373488 hasRelatedWork W1532617462 @default.
- W4313373488 hasRelatedWork W2059346471 @default.
- W4313373488 hasRelatedWork W2789804395 @default.
- W4313373488 hasRelatedWork W2897587086 @default.
- W4313373488 hasRelatedWork W2959474424 @default.
- W4313373488 hasRelatedWork W3030177861 @default.
- W4313373488 hasRelatedWork W3115204872 @default.
- W4313373488 hasRelatedWork W4221009692 @default.
- W4313373488 hasRelatedWork W4283511960 @default.
- W4313373488 hasRelatedWork W4313373488 @default.
- W4313373488 hasVolume "204" @default.
- W4313373488 isParatext "false" @default.
- W4313373488 isRetracted "false" @default.
- W4313373488 workType "article" @default.