Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313397443> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4313397443 endingPage "539" @default.
- W4313397443 startingPage "532" @default.
- W4313397443 abstract "Monitoring safety outcomes following COVID-19 vaccination is critical for understanding vaccine safety especially when used in key populations such as elderly persons age 65 years and older who can benefit greatly from vaccination. We present new findings from a nationally representative early warning system that may expand the safety knowledge base to further public trust and inform decision making on vaccine safety by government agencies, healthcare providers, interested stakeholders, and the public.We evaluated 14 outcomes of interest following COVID-19 vaccination using the US Centers for Medicare & Medicaid Services (CMS) data covering 30,712,101 elderly persons. The CMS data from December 11, 2020 through Jan 15, 2022 included 17,411,342 COVID-19 vaccinees who received a total of 34,639,937 doses. We conducted weekly sequential testing and generated rate ratios (RR) of observed outcome rates compared to historical (or expected) rates prior to COVID-19 vaccination.Four outcomes met the threshold for a statistical signal following BNT162b2 vaccination including pulmonary embolism (PE; RR = 1.54), acute myocardial infarction (AMI; RR = 1.42), disseminated intravascular coagulation (DIC; RR = 1.91), and immune thrombocytopenia (ITP; RR = 1.44). After further evaluation, only the RR for PE still met the statistical threshold for a signal; however, the RRs for AMI, DIC, and ITP no longer did. No statistical signals were identified following vaccination with either the mRNA-1273 or Ad26 COV2.S vaccines.This early warning system is the first to identify temporal associations for PE, AMI, DIC, and ITP following BNT162b2 vaccination in the elderly. Because an early warning system does not prove that the vaccines cause these outcomes, more robust epidemiologic studies with adjustment for confounding, including age and nursing home residency, are underway to further evaluate these signals. FDA strongly believes the potential benefits of COVID-19 vaccination outweigh the potential risks of COVID-19 infection." @default.
- W4313397443 created "2023-01-06" @default.
- W4313397443 creator A5008758398 @default.
- W4313397443 creator A5014245776 @default.
- W4313397443 creator A5022645240 @default.
- W4313397443 creator A5024452899 @default.
- W4313397443 creator A5030066738 @default.
- W4313397443 creator A5047323010 @default.
- W4313397443 creator A5048412798 @default.
- W4313397443 creator A5049580726 @default.
- W4313397443 creator A5049812814 @default.
- W4313397443 creator A5053965140 @default.
- W4313397443 creator A5063845988 @default.
- W4313397443 creator A5071722590 @default.
- W4313397443 creator A5072427629 @default.
- W4313397443 creator A5074231210 @default.
- W4313397443 creator A5087332112 @default.
- W4313397443 creator A5087944869 @default.
- W4313397443 date "2023-01-01" @default.
- W4313397443 modified "2023-10-02" @default.
- W4313397443 title "Surveillance of COVID-19 vaccine safety among elderly persons aged 65 years and older" @default.
- W4313397443 cites W2023071006 @default.
- W4313397443 cites W2026666131 @default.
- W4313397443 cites W2055000866 @default.
- W4313397443 cites W2097005441 @default.
- W4313397443 cites W2098104511 @default.
- W4313397443 cites W2608916358 @default.
- W4313397443 cites W2946790770 @default.
- W4313397443 cites W2972586635 @default.
- W4313397443 cites W3111037573 @default.
- W4313397443 cites W3114735216 @default.
- W4313397443 doi "https://doi.org/10.1016/j.vaccine.2022.11.069" @default.
- W4313397443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36496287" @default.
- W4313397443 hasPublicationYear "2023" @default.
- W4313397443 type Work @default.
- W4313397443 citedByCount "5" @default.
- W4313397443 countsByYear W43133974432023 @default.
- W4313397443 crossrefType "journal-article" @default.
- W4313397443 hasAuthorship W4313397443A5008758398 @default.
- W4313397443 hasAuthorship W4313397443A5014245776 @default.
- W4313397443 hasAuthorship W4313397443A5022645240 @default.
- W4313397443 hasAuthorship W4313397443A5024452899 @default.
- W4313397443 hasAuthorship W4313397443A5030066738 @default.
- W4313397443 hasAuthorship W4313397443A5047323010 @default.
- W4313397443 hasAuthorship W4313397443A5048412798 @default.
- W4313397443 hasAuthorship W4313397443A5049580726 @default.
- W4313397443 hasAuthorship W4313397443A5049812814 @default.
- W4313397443 hasAuthorship W4313397443A5053965140 @default.
- W4313397443 hasAuthorship W4313397443A5063845988 @default.
- W4313397443 hasAuthorship W4313397443A5071722590 @default.
- W4313397443 hasAuthorship W4313397443A5072427629 @default.
- W4313397443 hasAuthorship W4313397443A5074231210 @default.
- W4313397443 hasAuthorship W4313397443A5087332112 @default.
- W4313397443 hasAuthorship W4313397443A5087944869 @default.
- W4313397443 hasBestOaLocation W43133974432 @default.
- W4313397443 hasConcept C160735492 @default.
- W4313397443 hasConcept C162324750 @default.
- W4313397443 hasConcept C194828623 @default.
- W4313397443 hasConcept C203014093 @default.
- W4313397443 hasConcept C22070199 @default.
- W4313397443 hasConcept C2776534028 @default.
- W4313397443 hasConcept C50522688 @default.
- W4313397443 hasConcept C545542383 @default.
- W4313397443 hasConcept C71924100 @default.
- W4313397443 hasConceptScore W4313397443C160735492 @default.
- W4313397443 hasConceptScore W4313397443C162324750 @default.
- W4313397443 hasConceptScore W4313397443C194828623 @default.
- W4313397443 hasConceptScore W4313397443C203014093 @default.
- W4313397443 hasConceptScore W4313397443C22070199 @default.
- W4313397443 hasConceptScore W4313397443C2776534028 @default.
- W4313397443 hasConceptScore W4313397443C50522688 @default.
- W4313397443 hasConceptScore W4313397443C545542383 @default.
- W4313397443 hasConceptScore W4313397443C71924100 @default.
- W4313397443 hasFunder F4320332163 @default.
- W4313397443 hasFunder F4320332401 @default.
- W4313397443 hasIssue "2" @default.
- W4313397443 hasLocation W43133974431 @default.
- W4313397443 hasLocation W43133974432 @default.
- W4313397443 hasLocation W43133974433 @default.
- W4313397443 hasLocation W43133974434 @default.
- W4313397443 hasOpenAccess W4313397443 @default.
- W4313397443 hasPrimaryLocation W43133974431 @default.
- W4313397443 hasRelatedWork W2083479052 @default.
- W4313397443 hasRelatedWork W2156182319 @default.
- W4313397443 hasRelatedWork W2163615598 @default.
- W4313397443 hasRelatedWork W270901988 @default.
- W4313397443 hasRelatedWork W2790236813 @default.
- W4313397443 hasRelatedWork W3012801339 @default.
- W4313397443 hasRelatedWork W3016731769 @default.
- W4313397443 hasRelatedWork W3020181358 @default.
- W4313397443 hasRelatedWork W4205354303 @default.
- W4313397443 hasRelatedWork W4282018554 @default.
- W4313397443 hasVolume "41" @default.
- W4313397443 isParatext "false" @default.
- W4313397443 isRetracted "false" @default.
- W4313397443 workType "article" @default.