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- W4313445997 abstract "Certain glycolipids have immunomodulatory potential by activating natural killer T (NKT) cells, a unique T cell subset. Invariant NKT (iNKT) cells recognize α-galactosylceramide (α-GalCer) and synthetic derivatives presented by CD1d molecules and secrete large amounts of cytokines that modulate immune functions. Some iNKT cell ligands induce distinct reactions biased toward either Th1 or Th2 immune responses, while others show mixed responses. We describe the methods for activating iNKT cells by the ligands as represented by α-GalCer using in vitro assays, such as cell-free or co-culture with antigen-presenting cells. In addition, α-GalCer/CD1d multimer can be used to specifically detect iNKT cells using flow cytometry. α-GalCer is also utilized to activate systemic iNKT cells in vivo, which leads to the production of high levels of cytokines in sera. Collectively, α-GalCer and its derivatives activate iNKT cells that modulate immune balance, and we need to understand the characteristics of these ligands for developing their utility." @default.
- W4313445997 created "2023-01-06" @default.
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- W4313445997 date "2023-01-01" @default.
- W4313445997 modified "2023-09-23" @default.
- W4313445997 title "Immunomodulatory Functions of α-GalCer and a Derivative, α-Carba-GalCer" @default.
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- W4313445997 doi "https://doi.org/10.1007/978-1-0716-2910-9_1" @default.
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