Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313472788> ?p ?o ?g. }
- W4313472788 endingPage "659" @default.
- W4313472788 startingPage "659" @default.
- W4313472788 abstract "Alcohol and aldehyde dehydrogenases are especially relevant enzymes involved in metabolic and detoxification reactions that occur in living cells. The comparison between the gene expression, protein content, and enzymatic activities of cytosolic alcohol and aldehyde dehydrogenases of the wild-type strain and the Δsod1 mutant lacking superoxide dismutase 1, which is hypersensitive to alcohols and aldehydes, shows that the activity of these enzymes is significantly higher in the Δsod1 mutant, but this is not a mere consequence of differences in the enzymatic protein content nor in the expression levels of genes. The analysis of the NAD(H) and NADP(H) content showed that the higher activity of alcohol and aldehyde dehydrogenases in the Δsod1 mutant could be a result of the increased availability of pyridine nucleotide cofactors. The higher level of NAD+ in the Δsod1 mutant is not related to the higher level of tryptophan; in turn, a higher generation of NADPH is associated with the upregulation of the pentose phosphate pathway. It is concluded that the increased sensitivity of the Δsod1 mutant to alcohols and aldehydes is not only a result of the disorder of redox homeostasis caused by the induction of oxidative stress but also a consequence of the unbalance between pyridine nucleotide cofactors." @default.
- W4313472788 created "2023-01-06" @default.
- W4313472788 creator A5029886444 @default.
- W4313472788 creator A5034675324 @default.
- W4313472788 creator A5041033147 @default.
- W4313472788 creator A5042886959 @default.
- W4313472788 creator A5072848986 @default.
- W4313472788 creator A5080695248 @default.
- W4313472788 date "2022-12-30" @default.
- W4313472788 modified "2023-10-18" @default.
- W4313472788 title "Unbalance between Pyridine Nucleotide Cofactors in The SOD1 Deficient Yeast Saccharomyces cerevisiae Causes Hypersensitivity to Alcohols and Aldehydes" @default.
- W4313472788 cites W111496566 @default.
- W4313472788 cites W1536128494 @default.
- W4313472788 cites W1596414641 @default.
- W4313472788 cites W1668458589 @default.
- W4313472788 cites W1848905263 @default.
- W4313472788 cites W1969052338 @default.
- W4313472788 cites W1974608463 @default.
- W4313472788 cites W1977523943 @default.
- W4313472788 cites W1981123464 @default.
- W4313472788 cites W1986408429 @default.
- W4313472788 cites W1987861061 @default.
- W4313472788 cites W1988378787 @default.
- W4313472788 cites W1998447705 @default.
- W4313472788 cites W1998566045 @default.
- W4313472788 cites W1998853178 @default.
- W4313472788 cites W2000651474 @default.
- W4313472788 cites W2002279109 @default.
- W4313472788 cites W2009647128 @default.
- W4313472788 cites W2012604980 @default.
- W4313472788 cites W2014477641 @default.
- W4313472788 cites W2018227196 @default.
- W4313472788 cites W2018289835 @default.
- W4313472788 cites W2018928882 @default.
- W4313472788 cites W2022255882 @default.
- W4313472788 cites W2036669328 @default.
- W4313472788 cites W2038979858 @default.
- W4313472788 cites W2053620269 @default.
- W4313472788 cites W2053904934 @default.
- W4313472788 cites W2057522312 @default.
- W4313472788 cites W2060440525 @default.
- W4313472788 cites W2061138506 @default.
- W4313472788 cites W2062766197 @default.
- W4313472788 cites W2062950161 @default.
- W4313472788 cites W2063464385 @default.
- W4313472788 cites W2071672028 @default.
- W4313472788 cites W2073689485 @default.
- W4313472788 cites W2074368204 @default.
- W4313472788 cites W2076477755 @default.
- W4313472788 cites W2084075818 @default.
- W4313472788 cites W2086017419 @default.
- W4313472788 cites W2086695931 @default.
- W4313472788 cites W2089042385 @default.
- W4313472788 cites W2092124012 @default.
- W4313472788 cites W2093768752 @default.
- W4313472788 cites W2100837269 @default.
- W4313472788 cites W2114025452 @default.
- W4313472788 cites W2114570899 @default.
- W4313472788 cites W2132746534 @default.
- W4313472788 cites W2133552928 @default.
- W4313472788 cites W2158749368 @default.
- W4313472788 cites W2161861367 @default.
- W4313472788 cites W2168328195 @default.
- W4313472788 cites W2199990043 @default.
- W4313472788 cites W2232394370 @default.
- W4313472788 cites W2321073025 @default.
- W4313472788 cites W2342014232 @default.
- W4313472788 cites W2555090399 @default.
- W4313472788 cites W2722324655 @default.
- W4313472788 cites W2793369871 @default.
- W4313472788 cites W2896692266 @default.
- W4313472788 cites W2903476670 @default.
- W4313472788 cites W2939791112 @default.
- W4313472788 cites W3041892367 @default.
- W4313472788 cites W313706751 @default.
- W4313472788 doi "https://doi.org/10.3390/ijms24010659" @default.
- W4313472788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36614102" @default.
- W4313472788 hasPublicationYear "2022" @default.
- W4313472788 type Work @default.
- W4313472788 citedByCount "1" @default.
- W4313472788 countsByYear W43134727882023 @default.
- W4313472788 crossrefType "journal-article" @default.
- W4313472788 hasAuthorship W4313472788A5029886444 @default.
- W4313472788 hasAuthorship W4313472788A5034675324 @default.
- W4313472788 hasAuthorship W4313472788A5041033147 @default.
- W4313472788 hasAuthorship W4313472788A5042886959 @default.
- W4313472788 hasAuthorship W4313472788A5072848986 @default.
- W4313472788 hasAuthorship W4313472788A5080695248 @default.
- W4313472788 hasBestOaLocation W43134727881 @default.
- W4313472788 hasConcept C104317684 @default.
- W4313472788 hasConcept C143065580 @default.
- W4313472788 hasConcept C181199279 @default.
- W4313472788 hasConcept C185592680 @default.
- W4313472788 hasConcept C197957613 @default.
- W4313472788 hasConcept C25747580 @default.
- W4313472788 hasConcept C2775838275 @default.
- W4313472788 hasConcept C2777615887 @default.
- W4313472788 hasConcept C2779222958 @default.