FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313509595> ?p ?o ?g. }

• W4313509595 abstract "Sepsis is a systemic inflammatory response syndrome, mainly caused by infection or suspected infectious factors. The intestine is not only one of the most easily involved organs in the course of sepsis, but also the dynamic organ for the course of sepsis. The present study investigated the protective effect and mechanism of salidroside on intestinal barrier dysfunction of septic mice. Briefly, C57BL/6 mice were used to establish a septic model and then administered with salidroside. The ileum tissues of mice were examined by histopathological examination. Fluorescein isothiocyanate-dextran concentration was measured. IL-17, IL-6, IL-13 and TNF-α levels in ileum tissues and NF-κB and p38 MAPK activations were detected by ELISA and the expressions of NF-κB p65 and p38 MAPK protein with their phosphorylation and intestinal tight junction proteins were gauged by western blotting. The above assays were performed again to investigate the effect of anti-IL-17A and salidroside (160 mg/kg) alone or in combination. The septic model induced the ileum tissue injury, increased intestinal permeability and TNF-α, IL-17 and IL-6 levels, activated NF-κB and p38 MAPK pathways, promoted the expressions of NF-κB p65 and p38 MAPK and their phosphorylation, while suppressing the levels of IL-13 and intestinal tight junction proteins. Salidroside and anti-IL-17A partially reversed the above effects of septic model, which in combination further strengthened the reversing effect. Collectively, salidroside protected against intestinal barrier dysfunction in septic mice by downregulating IL-17 level to inhibit NF-κB and p38 MAPK signaling pathways, thus providing a new treatment direction." @default.
• W4313509595 created "2023-01-06" @default.
• W4313509595 creator A5027054964 @default.
• W4313509595 creator A5057131883 @default.
• W4313509595 creator A5057676286 @default.
• W4313509595 creator A5077489137 @default.
• W4313509595 date "2023-01-05" @default.
• W4313509595 modified "2023-09-30" @default.
• W4313509595 title "Salidroside protects against intestinal barrier dysfunction in septic mice by regulating IL‑17 to block the NF‑κB and p38 MAPK signaling pathways" @default.
• W4313509595 cites W1568265476 @default.
• W4313509595 cites W1825470131 @default.
• W4313509595 cites W1836263069 @default.
• W4313509595 cites W1966028740 @default.
• W4313509595 cites W2000593246 @default.
• W4313509595 cites W2001857046 @default.
• W4313509595 cites W2006787199 @default.
• W4313509595 cites W2014785961 @default.
• W4313509595 cites W2022015231 @default.
• W4313509595 cites W2033229647 @default.
• W4313509595 cites W2048176469 @default.
• W4313509595 cites W2050524172 @default.
• W4313509595 cites W2052117755 @default.
• W4313509595 cites W2085187432 @default.
• W4313509595 cites W2092509739 @default.
• W4313509595 cites W2118844654 @default.
• W4313509595 cites W2130887303 @default.
• W4313509595 cites W2131196233 @default.
• W4313509595 cites W2156753993 @default.
• W4313509595 cites W2278600110 @default.
• W4313509595 cites W2289740209 @default.
• W4313509595 cites W2319166398 @default.
• W4313509595 cites W2339813221 @default.
• W4313509595 cites W2397284278 @default.
• W4313509595 cites W2590668924 @default.
• W4313509595 cites W2612637999 @default.
• W4313509595 cites W2624797255 @default.
• W4313509595 cites W2744300542 @default.
• W4313509595 cites W2754559965 @default.
• W4313509595 cites W2755691040 @default.
• W4313509595 cites W2767478133 @default.
• W4313509595 cites W2775837711 @default.
• W4313509595 cites W2803156147 @default.
• W4313509595 cites W2883148575 @default.
• W4313509595 cites W2883191655 @default.
• W4313509595 cites W2886035231 @default.
• W4313509595 cites W2901007321 @default.
• W4313509595 cites W2903214522 @default.
• W4313509595 cites W2903643400 @default.
• W4313509595 cites W2919845093 @default.
• W4313509595 cites W2921822951 @default.
• W4313509595 cites W2922495100 @default.
• W4313509595 cites W2939532730 @default.
• W4313509595 cites W2942645055 @default.
• W4313509595 cites W2967777612 @default.
• W4313509595 cites W2982020262 @default.
• W4313509595 cites W2983871227 @default.
• W4313509595 cites W2991266307 @default.
• W4313509595 cites W2996172831 @default.
• W4313509595 cites W2999147840 @default.
• W4313509595 cites W3013584557 @default.
• W4313509595 cites W3024880888 @default.
• W4313509595 cites W3048217529 @default.
• W4313509595 cites W3081415537 @default.
• W4313509595 cites W3087515135 @default.
• W4313509595 cites W3103802408 @default.
• W4313509595 cites W3136636988 @default.
• W4313509595 cites W3186903307 @default.
• W4313509595 cites W3204205200 @default.
• W4313509595 cites W774691086 @default.
• W4313509595 doi "https://doi.org/10.3892/etm.2023.11788" @default.
• W4313509595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36684648" @default.
• W4313509595 hasPublicationYear "2023" @default.
• W4313509595 type Work @default.
• W4313509595 citedByCount "1" @default.
• W4313509595 countsByYear W43135095952023 @default.
• W4313509595 crossrefType "journal-article" @default.
• W4313509595 hasAuthorship W4313509595A5027054964 @default.
• W4313509595 hasAuthorship W4313509595A5057131883 @default.
• W4313509595 hasAuthorship W4313509595A5057676286 @default.
• W4313509595 hasAuthorship W4313509595A5077489137 @default.
• W4313509595 hasBestOaLocation W43135095951 @default.
• W4313509595 hasConcept C11960822 @default.
• W4313509595 hasConcept C134018914 @default.
• W4313509595 hasConcept C17991360 @default.
• W4313509595 hasConcept C203014093 @default.
• W4313509595 hasConcept C2776914184 @default.
• W4313509595 hasConcept C2777226302 @default.
• W4313509595 hasConcept C2777730290 @default.
• W4313509595 hasConcept C2778384902 @default.
• W4313509595 hasConcept C2779526882 @default.
• W4313509595 hasConcept C51551487 @default.
• W4313509595 hasConcept C57074206 @default.
• W4313509595 hasConcept C71924100 @default.
• W4313509595 hasConcept C86803240 @default.
• W4313509595 hasConcept C95444343 @default.
• W4313509595 hasConcept C98274493 @default.
• W4313509595 hasConceptScore W4313509595C11960822 @default.
• W4313509595 hasConceptScore W4313509595C134018914 @default.
• W4313509595 hasConceptScore W4313509595C17991360 @default.
• W4313509595 hasConceptScore W4313509595C203014093 @default.

• next