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• W4313584502 abstract "In recent decades, the Notch pathway has been characterized as a key regulatory signaling of cell-fate decisions evolutionarily conserved in many organisms and different tissues during lifespan. At the same time, many studies suggest a link between alterations of this signaling and tumor genesis or progression. In lymphopoiesis, the Notch pathway plays a fundamental role in the correct differentiation of T and B cells, but its deregulated activity leads to leukemic onset and evolution. Notch and its ligands Delta/Jagged exhibit a pivotal role in the crosstalk between leukemic cells and their environment. This review is focused in particular on Notch2 receptor activity. Members of Notch2 pathway have been reported to be mutated in Chronic Lymphocytic Leukemia (CLL), Splenic Marginal Zone Lymphoma (SMZL) and Nodal Marginal Zone Lymphoma (NMZL). CLL is a B cell malignancy in which leukemic clones establish supportive crosstalk with non-malignant cells of the tumor microenvironment to grow, survive, and resist even the new generation of drugs. SMZL and NMZL are indolent B cell neoplasms distinguished by a distinct pattern of dissemination. In SMZL leukemic cells affect mainly the spleen, bone marrow, and peripheral blood, while NMZL has a leading nodal distribution. Since Notch2 is involved in the commitment of leukemic cells to the marginal zone as a major regulator of B cell physiological differentiation, it is predominantly affected by the molecular lesions found in both SMZL and NMZL. In light of these findings, a better understanding of the Notch receptor family pathogenic role, in particular Notch2, is desirable because it is still incomplete, not only in the physiological development of B lymphocytes but also in leukemia progression and resistance. Several therapeutic strategies capable of interfering with Notch signaling, such as monoclonal antibodies, enzyme or complex inhibitors, are being analyzed. To avoid the unwanted multiple on target toxicity encountered during the systemic inhibition of Notch signaling, the study of an appropriate pharmaceutical formulation is a pressing need. This is why, to date, there are still no Notch-targeted therapies approved. An accurate analysis of the Notch pathway could be useful to drive the discovery of new therapeutic targets and the development of more effective therapies." @default.
• W4313584502 created "2023-01-06" @default.
• W4313584502 creator A5003361632 @default.
• W4313584502 creator A5008526145 @default.
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• W4313584502 creator A5079365060 @default.
• W4313584502 creator A5080861890 @default.
• W4313584502 creator A5089902749 @default.
• W4313584502 date "2023-01-04" @default.
• W4313584502 modified "2023-10-14" @default.
• W4313584502 title "Role of Notch2 pathway in mature B cell malignancies" @default.
• W4313584502 cites W1016810471 @default.
• W4313584502 cites W1595935608 @default.
• W4313584502 cites W1660631781 @default.
• W4313584502 cites W1750541350 @default.
• W4313584502 cites W1859056059 @default.
• W4313584502 cites W1965493170 @default.
• W4313584502 cites W1967051571 @default.
• W4313584502 cites W1969057487 @default.
• W4313584502 cites W1972496597 @default.
• W4313584502 cites W1972700012 @default.
• W4313584502 cites W1973388908 @default.
• W4313584502 cites W1976073214 @default.
• W4313584502 cites W1977962361 @default.
• W4313584502 cites W1980212327 @default.
• W4313584502 cites W1980431535 @default.
• W4313584502 cites W1982158899 @default.
• W4313584502 cites W1983360116 @default.
• W4313584502 cites W1988752936 @default.
• W4313584502 cites W1989024966 @default.
• W4313584502 cites W1991863709 @default.
• W4313584502 cites W1992126416 @default.
• W4313584502 cites W1993355130 @default.
• W4313584502 cites W1995667263 @default.
• W4313584502 cites W1995863606 @default.
• W4313584502 cites W1996344090 @default.
• W4313584502 cites W1996452057 @default.
• W4313584502 cites W1999767718 @default.
• W4313584502 cites W2000589976 @default.
• W4313584502 cites W2001781763 @default.
• W4313584502 cites W2008295869 @default.
• W4313584502 cites W2009163796 @default.
• W4313584502 cites W2017253762 @default.
• W4313584502 cites W2017470814 @default.
• W4313584502 cites W2018527149 @default.
• W4313584502 cites W2018868898 @default.
• W4313584502 cites W2020467756 @default.
• W4313584502 cites W2021803232 @default.
• W4313584502 cites W2025462312 @default.
• W4313584502 cites W2026140964 @default.
• W4313584502 cites W2028561648 @default.
• W4313584502 cites W2034458870 @default.
• W4313584502 cites W2036385874 @default.
• W4313584502 cites W2039505162 @default.
• W4313584502 cites W2039623436 @default.
• W4313584502 cites W2040929949 @default.
• W4313584502 cites W2040947899 @default.
• W4313584502 cites W2041492033 @default.
• W4313584502 cites W2041572974 @default.
• W4313584502 cites W2042082068 @default.
• W4313584502 cites W2042534735 @default.
• W4313584502 cites W2044826816 @default.
• W4313584502 cites W2046267268 @default.
• W4313584502 cites W2049948540 @default.
• W4313584502 cites W2050700188 @default.
• W4313584502 cites W2053924952 @default.
• W4313584502 cites W2060710804 @default.
• W4313584502 cites W2061996746 @default.
• W4313584502 cites W2062084323 @default.
• W4313584502 cites W2062612507 @default.
• W4313584502 cites W2067354786 @default.
• W4313584502 cites W2070640889 @default.
• W4313584502 cites W2071017995 @default.
• W4313584502 cites W2071786488 @default.
• W4313584502 cites W2074112118 @default.
• W4313584502 cites W2074159015 @default.
• W4313584502 cites W2077851237 @default.
• W4313584502 cites W2078497756 @default.
• W4313584502 cites W2081471404 @default.
• W4313584502 cites W2083425643 @default.
• W4313584502 cites W2085948054 @default.
• W4313584502 cites W2086677653 @default.
• W4313584502 cites W2088720735 @default.
• W4313584502 cites W2089184470 @default.
• W4313584502 cites W2091838381 @default.
• W4313584502 cites W2092845380 @default.
• W4313584502 cites W2095397411 @default.
• W4313584502 cites W2097957857 @default.
• W4313584502 cites W2103267380 @default.
• W4313584502 cites W2108991206 @default.
• W4313584502 cites W2112622667 @default.
• W4313584502 cites W2113337076 @default.
• W4313584502 cites W2116431837 @default.
• W4313584502 cites W2116965161 @default.
• W4313584502 cites W2117775564 @default.
• W4313584502 cites W2118159230 @default.
• W4313584502 cites W2119005151 @default.
• W4313584502 cites W2119309845 @default.
• W4313584502 cites W2134349499 @default.

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