FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313894459> ?p ?o ?g. }

• W4313894459 abstract "Introduction: Despite the high need for effective treatments for major depressive disorder (MDD), the development of novel medicines is hampered by clinical, genetic and biological heterogeneity, unclear links between symptoms and neural dysfunction, and tenuous biomarkers for clinical trial contexts of use. Methods: In this study, we examined the International Study to Predict Optimized Treatment in Depression (iSPOT-D) clinical trial database for new relationships between auditory event-related potential (ERP) responses, demographic features, and clinical symptoms and behavior, to inform strategies for biomarker-driven patient stratification that could be used to optimize future clinical trial design and drug development strategy in MDD. Results: We replicate findings from previous analyses of the classic auditory oddball task in the iSPOT-D sample showing smaller than typical N1 and P300 response amplitudes and longer P300 latencies for target and standard stimuli in patients with MDD, suggesting altered bottom-up sensory and top-down attentional processes. We further demonstrate that age is an important contributor to clinical group differences, affecting both topographic distribution of the clinically informative ERP responses and the types of the stimuli sensitive to group differences. In addition, the observed brain-behavior associations indicate that levels of anxiety and stress are major contributing factors to atypical sensory and attentional processing among patients with MDD, particularly in the older subgroups. Discussion: Our novel findings support the possibility of accelerated cognitive aging in patients with MDD and identify the frontal P300 latency as an additional candidate biomarker of MDD. These results from a large, well-phenotyped sample support the view that heterogeneity of the clinical population with MDD can be systematically characterized based on age and neural biomarkers of sensory and attentional processing, informing patient stratification strategies in the design of clinical trials." @default.
• W4313894459 created "2023-01-10" @default.
• W4313894459 creator A5033855899 @default.
• W4313894459 creator A5049773166 @default.
• W4313894459 creator A5064962614 @default.
• W4313894459 date "2023-01-09" @default.
• W4313894459 modified "2023-09-30" @default.
• W4313894459 title "Electrophysiological biomarkers and age characterize phenotypic heterogeneity among individuals with major depressive disorder" @default.
• W4313894459 cites W1005459783 @default.
• W4313894459 cites W1091352033 @default.
• W4313894459 cites W1413510374 @default.
• W4313894459 cites W19412929 @default.
• W4313894459 cites W1945849375 @default.
• W4313894459 cites W1950282921 @default.
• W4313894459 cites W1965665196 @default.
• W4313894459 cites W1968203178 @default.
• W4313894459 cites W1968435421 @default.
• W4313894459 cites W1970133878 @default.
• W4313894459 cites W1977127683 @default.
• W4313894459 cites W1982363459 @default.
• W4313894459 cites W1983446437 @default.
• W4313894459 cites W1991002654 @default.
• W4313894459 cites W1995942616 @default.
• W4313894459 cites W1997280537 @default.
• W4313894459 cites W199766156 @default.
• W4313894459 cites W1997918569 @default.
• W4313894459 cites W1998001226 @default.
• W4313894459 cites W1999682854 @default.
• W4313894459 cites W2001681699 @default.
• W4313894459 cites W2002313059 @default.
• W4313894459 cites W2004327382 @default.
• W4313894459 cites W2005124365 @default.
• W4313894459 cites W2006418362 @default.
• W4313894459 cites W2011577724 @default.
• W4313894459 cites W2014459859 @default.
• W4313894459 cites W2015346630 @default.
• W4313894459 cites W2015599047 @default.
• W4313894459 cites W2018236778 @default.
• W4313894459 cites W2022167326 @default.
• W4313894459 cites W2028257259 @default.
• W4313894459 cites W2029669121 @default.
• W4313894459 cites W2034861585 @default.
• W4313894459 cites W2051378103 @default.
• W4313894459 cites W2052106863 @default.
• W4313894459 cites W2061760871 @default.
• W4313894459 cites W2065743523 @default.
• W4313894459 cites W2070066822 @default.
• W4313894459 cites W2076163941 @default.
• W4313894459 cites W2077862643 @default.
• W4313894459 cites W2082757365 @default.
• W4313894459 cites W2088173555 @default.
• W4313894459 cites W2099854208 @default.
• W4313894459 cites W2104640717 @default.
• W4313894459 cites W2105732570 @default.
• W4313894459 cites W2111979641 @default.
• W4313894459 cites W2112724572 @default.
• W4313894459 cites W2114512489 @default.
• W4313894459 cites W2126104386 @default.
• W4313894459 cites W2131894812 @default.
• W4313894459 cites W2132633462 @default.
• W4313894459 cites W2136372468 @default.
• W4313894459 cites W2137296158 @default.
• W4313894459 cites W2139821383 @default.
• W4313894459 cites W2140787893 @default.
• W4313894459 cites W2148448579 @default.
• W4313894459 cites W2150037324 @default.
• W4313894459 cites W2150111222 @default.
• W4313894459 cites W2154083238 @default.
• W4313894459 cites W2161299701 @default.
• W4313894459 cites W2168432043 @default.
• W4313894459 cites W2258625169 @default.
• W4313894459 cites W2321418734 @default.
• W4313894459 cites W2460740376 @default.
• W4313894459 cites W2537654815 @default.
• W4313894459 cites W2578106981 @default.
• W4313894459 cites W2622736281 @default.
• W4313894459 cites W2748403497 @default.
• W4313894459 cites W2800301228 @default.
• W4313894459 cites W2808181523 @default.
• W4313894459 cites W2894370815 @default.
• W4313894459 cites W2909674457 @default.
• W4313894459 cites W2923773053 @default.
• W4313894459 cites W2965297587 @default.
• W4313894459 cites W3048792238 @default.
• W4313894459 cites W3118875409 @default.
• W4313894459 cites W3124593434 @default.
• W4313894459 cites W3163489461 @default.
• W4313894459 cites W4210404526 @default.
• W4313894459 cites W4249392436 @default.
• W4313894459 cites W4285498906 @default.
• W4313894459 cites W4297984686 @default.
• W4313894459 cites W4309659052 @default.
• W4313894459 cites W52313541 @default.
• W4313894459 cites W809627097 @default.
• W4313894459 doi "https://doi.org/10.3389/fnhum.2022.1055685" @default.
• W4313894459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36699961" @default.
• W4313894459 hasPublicationYear "2023" @default.
• W4313894459 type Work @default.
• W4313894459 citedByCount "1" @default.
• W4313894459 countsByYear W43138944592023 @default.

• next