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- W4315703401 endingPage "864" @default.
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- W4315703401 abstract "Chemodynamic therapy (CDT) has been considered an emerging strategy for cancer treatment. However, the tumor microenvironment (TME) with slight acidity and restricted H2O2 limits the efficacy of CDT. Here, we report a Hf-Mn-TCPP (Hf = hafnium; Mn-TCPP = 5, 10, 15, 20-tetrakis (4-carboxyphenyl) porphyrinato-manganese (II) chloride) loaded with glucose oxidase (GOx) to realize starving-enhanced CDT. GOx consumes glucose to produce H2O2 and gluconic acid. Gluconic acid increases the acidity of TME and subsequently provides favorable conditions for the Fenton-like reaction based on Hf-Mn-TCPP. The results indicate that GOx-modified Hf-Mn-TCPP provided a great therapeutic effect in starvation-enhanced CDT in vitro and in vivo." @default.
- W4315703401 created "2023-01-12" @default.
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- W4315703401 date "2023-01-12" @default.
- W4315703401 modified "2023-10-18" @default.
- W4315703401 title "Glucose Oxidase-Modified Metal–Organic Framework for Starving-Enhanced Chemodynamic Therapy" @default.
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- W4315703401 doi "https://doi.org/10.1021/acsabm.2c01004" @default.
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- W4315703401 hasPublicationYear "2023" @default.
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