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• W4316363144 abstract "Background Docetaxel improves overall survival (OS) in castration-resistant prostate cancer (PCa) (CRPC) and metastatic hormone-sensitive PCa (mHSPC). However, not all patients respond due to inherent and/or acquired resistance. There remains an unmet clinical need for a robust predictive test to stratify patients for treatment. Liquid biopsy of circulating tumour cell (CTCs) is minimally invasive, can provide real-time information of the heterogeneous tumour and therefore may be a potentially ideal docetaxel response prediction biomarker. Objective In this study we investigate the potential of using CTCs and their gene expression to predict post-docetaxel tumour response, OS and progression free survival (PFS). Methods Peripheral blood was sampled from 18 mCRPC and 43 mHSPC patients, pre-docetaxel treatment, for CTC investigation. CTCs were isolated using the epitope independent Parsortix ® system and gene expression was determined by multiplex RT-qPCR. We evaluated CTC measurements for post-docetaxel outcome prediction using receiver operating characteristics and Kaplan Meier analysis. Results Detection of CTCs pre-docetaxel was associated with poor patient outcome post-docetaxel treatment. Combining total-CTC number with PSA and ALP predicted lack of partial response (PR) with an AUC of 0.90, p= 0.037 in mCRPC. A significantly shorter median OS was seen in mCRPC patients with positive CTC-score (12.80 vs. 37.33 months, HR= 5.08, p= 0.0005), ≥3 total-CTCs/7.5mL (12.80 vs. 37.33 months, HR= 3.84, p= 0.0053), ≥1 epithelial-CTCs/7.5mL (14.30 vs. 37.33 months, HR= 3.89, p= 0.0041) or epithelial to mesenchymal transitioning (EMTing)-CTCs/7.5mL (11.32 vs. 32.37 months, HR= 6.73, p= 0.0001). Significantly shorter PFS was observed in patients with ≥2 epithelial-CTCs/7.5mL (7.52 vs. 18.83 months, HR= 3.93, p= 0.0058). mHSPC patients with ≥5 CTCs/7.5mL had significantly shorter median OS (24.57 vs undefined months, HR= 4.14, p= 0.0097). In mHSPC patients, expression of KLK2 , KLK4 , ADAMTS1 , ZEB1 and SNAI1 was significantly associated with shorter OS and/or PFS. Importantly, combining CTC measurements with clinical biomarkers increased sensitivity and specificity for prediction of patient outcome. Conclusion While it is clear that CTC numbers and gene expression were prognostic for PCa post-docetaxel treatment, and CTC subtype analysis may have additional value, their potential predictive value for docetaxel chemotherapy response needs to be further investigated in large patient cohorts." @default.
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• W4316363144 date "2023-01-16" @default.
• W4316363144 modified "2023-10-18" @default.
• W4316363144 title "The potential of using circulating tumour cells and their gene expression to predict docetaxel response in metastatic prostate cancer" @default.
• W4316363144 cites W1842991947 @default.
• W4316363144 cites W1952921626 @default.
• W4316363144 cites W1984789674 @default.
• W4316363144 cites W1993307890 @default.
• W4316363144 cites W2020579083 @default.
• W4316363144 cites W2054082787 @default.
• W4316363144 cites W2067283190 @default.
• W4316363144 cites W2076149015 @default.
• W4316363144 cites W2085524876 @default.
• W4316363144 cites W2090091785 @default.
• W4316363144 cites W2100115202 @default.
• W4316363144 cites W2102099949 @default.
• W4316363144 cites W2102382046 @default.
• W4316363144 cites W2106572206 @default.
• W4316363144 cites W2120227082 @default.
• W4316363144 cites W2120292596 @default.
• W4316363144 cites W2139790154 @default.
• W4316363144 cites W2148998801 @default.
• W4316363144 cites W2150865892 @default.
• W4316363144 cites W2152073639 @default.
• W4316363144 cites W2157756773 @default.
• W4316363144 cites W2158732421 @default.
• W4316363144 cites W2159810380 @default.
• W4316363144 cites W2166374791 @default.
• W4316363144 cites W2179708332 @default.
• W4316363144 cites W2214621962 @default.
• W4316363144 cites W2287313802 @default.
• W4316363144 cites W2408795123 @default.
• W4316363144 cites W2516969383 @default.
• W4316363144 cites W2582775233 @default.
• W4316363144 cites W2597533471 @default.
• W4316363144 cites W2610389611 @default.
• W4316363144 cites W2610792799 @default.
• W4316363144 cites W2615103477 @default.
• W4316363144 cites W2626372827 @default.
• W4316363144 cites W2765792772 @default.
• W4316363144 cites W2767303656 @default.
• W4316363144 cites W2775990182 @default.
• W4316363144 cites W2787804990 @default.
• W4316363144 cites W2790264384 @default.
• W4316363144 cites W2796552195 @default.
• W4316363144 cites W2806604034 @default.
• W4316363144 cites W2889878104 @default.
• W4316363144 cites W2907445134 @default.
• W4316363144 cites W2909984150 @default.
• W4316363144 cites W2929950193 @default.
• W4316363144 cites W2957540433 @default.
• W4316363144 cites W2965546572 @default.
• W4316363144 cites W2966634342 @default.
• W4316363144 cites W3006507687 @default.
• W4316363144 cites W3008394635 @default.
• W4316363144 cites W3013894376 @default.
• W4316363144 cites W3039349546 @default.
• W4316363144 cites W3080179420 @default.
• W4316363144 cites W3095488812 @default.
• W4316363144 cites W3134382826 @default.
• W4316363144 cites W3138747339 @default.
• W4316363144 cites W3161782839 @default.
• W4316363144 cites W3217081290 @default.
• W4316363144 cites W4200579156 @default.
• W4316363144 cites W588539914 @default.
• W4316363144 doi "https://doi.org/10.3389/fonc.2022.1060864" @default.
• W4316363144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36727071" @default.
• W4316363144 hasPublicationYear "2023" @default.
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