Matches in SemOpenAlex for { <https://semopenalex.org/work/W4316465199> ?p ?o ?g. }
- W4316465199 endingPage "248" @default.
- W4316465199 startingPage "248" @default.
- W4316465199 abstract "The amaranthine scale of the COVID-19 pandemic and unpredictable disease severity is of grave concern. Serological diagnostic aids are an excellent choice for clinicians for rapid and easy prognosis of the disease. To this end, we studied the humoral immune response to SARS-CoV-2 infection to map immunogenic regions in the SARS-CoV-2 proteome at amino acid resolution using a high-density SARS-CoV-2 proteome peptide microarray. The microarray has 4932 overlapping peptides printed in duplicates spanning the entire SARS-CoV-2 proteome. We found 204 and 676 immunogenic peptides against IgA and IgG, corresponding to 137 and 412 IgA and IgG epitopes, respectively. Of these, 6 and 307 epitopes could discriminate between disease severity. The emergence of variants has added to the complexity of the disease. Using the mutation panel available, we could detect 5 and 10 immunogenic peptides against IgA and IgG with mutations belonging to SAR-CoV-2 variants. The study revealed severity-based epitopes that could be presented as potential prognostic serological markers. Further, the mutant epitope immunogenicity could indicate the putative use of these markers for diagnosing variants responsible for the infection." @default.
- W4316465199 created "2023-01-16" @default.
- W4316465199 creator A5008122028 @default.
- W4316465199 creator A5015787211 @default.
- W4316465199 creator A5018294900 @default.
- W4316465199 creator A5018816988 @default.
- W4316465199 creator A5023837367 @default.
- W4316465199 creator A5029106222 @default.
- W4316465199 creator A5053432866 @default.
- W4316465199 creator A5068477424 @default.
- W4316465199 creator A5071799003 @default.
- W4316465199 date "2023-01-15" @default.
- W4316465199 modified "2023-10-16" @default.
- W4316465199 title "Humoral Immune Response Profile of COVID-19 Reveals Severity and Variant-Specific Epitopes: Lessons from SARS-CoV-2 Peptide Microarray" @default.
- W4316465199 cites W2003555676 @default.
- W4316465199 cites W2031929435 @default.
- W4316465199 cites W2093289024 @default.
- W4316465199 cites W2110940238 @default.
- W4316465199 cites W2129169740 @default.
- W4316465199 cites W2130489595 @default.
- W4316465199 cites W2138916771 @default.
- W4316465199 cites W2146512944 @default.
- W4316465199 cites W2153300342 @default.
- W4316465199 cites W2164216268 @default.
- W4316465199 cites W2164466981 @default.
- W4316465199 cites W2400293920 @default.
- W4316465199 cites W2768064447 @default.
- W4316465199 cites W2886970059 @default.
- W4316465199 cites W3008443627 @default.
- W4316465199 cites W3016610966 @default.
- W4316465199 cites W3016655948 @default.
- W4316465199 cites W3016977245 @default.
- W4316465199 cites W3028711203 @default.
- W4316465199 cites W3029201461 @default.
- W4316465199 cites W3031410640 @default.
- W4316465199 cites W3035947543 @default.
- W4316465199 cites W3043427328 @default.
- W4316465199 cites W3044301527 @default.
- W4316465199 cites W3045737895 @default.
- W4316465199 cites W3049536383 @default.
- W4316465199 cites W3082131596 @default.
- W4316465199 cites W3084109555 @default.
- W4316465199 cites W3087903445 @default.
- W4316465199 cites W3091214020 @default.
- W4316465199 cites W3091805182 @default.
- W4316465199 cites W3093810077 @default.
- W4316465199 cites W3113376253 @default.
- W4316465199 cites W3115281787 @default.
- W4316465199 cites W3118528158 @default.
- W4316465199 cites W3118586020 @default.
- W4316465199 cites W3118776326 @default.
- W4316465199 cites W3121286195 @default.
- W4316465199 cites W3121365103 @default.
- W4316465199 cites W3124415907 @default.
- W4316465199 cites W3133520241 @default.
- W4316465199 cites W3136437538 @default.
- W4316465199 cites W3137091128 @default.
- W4316465199 cites W3148143574 @default.
- W4316465199 cites W3148747206 @default.
- W4316465199 cites W3157057412 @default.
- W4316465199 cites W3157779513 @default.
- W4316465199 cites W3159428982 @default.
- W4316465199 cites W3161468411 @default.
- W4316465199 cites W3188360386 @default.
- W4316465199 cites W3193592254 @default.
- W4316465199 cites W3196124078 @default.
- W4316465199 cites W4210438208 @default.
- W4316465199 cites W4220939068 @default.
- W4316465199 cites W4248025932 @default.
- W4316465199 cites W4281699968 @default.
- W4316465199 cites W4283018525 @default.
- W4316465199 doi "https://doi.org/10.3390/v15010248" @default.
- W4316465199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36680289" @default.
- W4316465199 hasPublicationYear "2023" @default.
- W4316465199 type Work @default.
- W4316465199 citedByCount "1" @default.
- W4316465199 countsByYear W43164651992023 @default.
- W4316465199 crossrefType "journal-article" @default.
- W4316465199 hasAuthorship W4316465199A5008122028 @default.
- W4316465199 hasAuthorship W4316465199A5015787211 @default.
- W4316465199 hasAuthorship W4316465199A5018294900 @default.
- W4316465199 hasAuthorship W4316465199A5018816988 @default.
- W4316465199 hasAuthorship W4316465199A5023837367 @default.
- W4316465199 hasAuthorship W4316465199A5029106222 @default.
- W4316465199 hasAuthorship W4316465199A5053432866 @default.
- W4316465199 hasAuthorship W4316465199A5068477424 @default.
- W4316465199 hasAuthorship W4316465199A5071799003 @default.
- W4316465199 hasBestOaLocation W43164651991 @default.
- W4316465199 hasConcept C104317684 @default.
- W4316465199 hasConcept C104397665 @default.
- W4316465199 hasConcept C142724271 @default.
- W4316465199 hasConcept C150194340 @default.
- W4316465199 hasConcept C159047783 @default.
- W4316465199 hasConcept C159654299 @default.
- W4316465199 hasConcept C186836561 @default.
- W4316465199 hasConcept C195616568 @default.
- W4316465199 hasConcept C203014093 @default.
- W4316465199 hasConcept C2779134260 @default.