Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321087961> ?p ?o ?g. }
- W4321087961 abstract "Neuroblastoma is one of the most common pediatric solid tumors that threaten the health of children, accounting for about 15% of childhood cancer-related mortality in the United States. Currently, multiple therapies have been developed and applied in clinic to treat neuroblastoma including chemotherapy, radiotherapy, targeted therapy, and immunotherapy. However, the resistance to therapies is inevitable following long-term treatment, leading to treatment failure and cancer relapse. Hence, to understand the mechanisms of therapy resistance and discover reversal strategies have become an urgent task. Recent studies have demonstrated numerous genetic alterations and dysfunctional pathways related to neuroblastoma resistance. These molecular signatures may be potential targets to combat refractory neuroblastoma. A number of novel interventions for neuroblastoma patients have been developed based on these targets. In this review, we focus on the complicated mechanisms of therapy resistance and the potential targets such as ATP-binding cassette transporters, long non-coding RNAs, microRNAs, autophagy, cancer stem cells, and extracellular vesicles. On this basis, we summarized recent studies on the reversal strategies to overcome therapy resistance of neuroblastoma such as targeting ATP-binding cassette transporters, MYCN gene, cancer stem cells, hypoxia, and autophagy. This review aims to provide novel insight in how to improve the therapy efficacy against resistant neuroblastoma, which may shed light on the future directions that would enhance the treatment outcomes and prolong the survival of patients with neuroblastoma." @default.
- W4321087961 created "2023-02-17" @default.
- W4321087961 creator A5000975799 @default.
- W4321087961 creator A5009903472 @default.
- W4321087961 creator A5015105154 @default.
- W4321087961 creator A5031617363 @default.
- W4321087961 creator A5035395627 @default.
- W4321087961 creator A5043539444 @default.
- W4321087961 date "2023-02-16" @default.
- W4321087961 modified "2023-10-10" @default.
- W4321087961 title "Therapy resistance in neuroblastoma: Mechanisms and reversal strategies" @default.
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