FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4328106153> ?p ?o ?g. }

• W4328106153 endingPage "569" @default.
• W4328106153 startingPage "569" @default.
• W4328106153 abstract "As of October 2022, the COVID-19 pandemic continues to pose a major public health conundrum, with increased rates of symptomatic infections in vaccinated individuals. An ideal vaccine candidate for the prevention of outbreaks should be rapidly scalable, easy to administer, and able to elicit a potent mucosal immunity. Towards this aim, we proposed an engineered Escherichia coli (E. coli) Nissle 1917 (EcN) strain with SARS-CoV-2 spike protein (SP)-coding plasmid, which was able to expose SP on its cellular surface by a hybridization with the adhesin involved in diffuse adherence 1 (AIDA1). In this study, we presented the effectiveness of a 16-week intragastrically administered, engineered EcN in producing specific systemic and mucosal immunoglobulins against SARS-CoV-2 SP in mice. We observed a time-dependent increase in anti-SARS-CoV-2 SP IgG antibodies in the sera at week 4, with a titre that more than doubled by week 12 and a stable circulating titre by week 16 (+309% and +325% vs. control; both p < 0.001). A parallel rise in mucosal IgA antibody titre in stools, measured via intestinal and bronchoalveolar lavage fluids of the treated mice, reached a plateau by week 12 and until the end of the immunization protocol (+300, +47, and +150%, at week 16; all p < 0.001 vs. controls). If confirmed in animal models of infection, our data indicated that the engineered EcN may be a potential candidate as an oral vaccine against COVID-19. It is safe, inexpensive, and, most importantly, able to stimulate the production of both systemic and mucosal anti-SARS-CoV-2 spike-protein antibodies." @default.
• W4328106153 created "2023-03-22" @default.
• W4328106153 creator A5013505611 @default.
• W4328106153 creator A5014566953 @default.
• W4328106153 creator A5028411489 @default.
• W4328106153 creator A5034204612 @default.
• W4328106153 creator A5035417175 @default.
• W4328106153 creator A5038183095 @default.
• W4328106153 creator A5040899311 @default.
• W4328106153 creator A5047657357 @default.
• W4328106153 creator A5048534767 @default.
• W4328106153 creator A5051721256 @default.
• W4328106153 creator A5051855397 @default.
• W4328106153 creator A5067931661 @default.
• W4328106153 creator A5074248134 @default.
• W4328106153 creator A5081631386 @default.
• W4328106153 date "2023-03-21" @default.
• W4328106153 modified "2023-10-18" @default.
• W4328106153 title "Oral Immunization with Escherichia coli Nissle 1917 Expressing SARS-CoV-2 Spike Protein Induces Mucosal and Systemic Antibody Responses in Mice" @default.
• W4328106153 cites W1597959509 @default.
• W4328106153 cites W1946050300 @default.
• W4328106153 cites W1977549443 @default.
• W4328106153 cites W1981555241 @default.
• W4328106153 cites W1985048571 @default.
• W4328106153 cites W1985381669 @default.
• W4328106153 cites W1993150792 @default.
• W4328106153 cites W2024614102 @default.
• W4328106153 cites W2063950598 @default.
• W4328106153 cites W2076446987 @default.
• W4328106153 cites W2081182500 @default.
• W4328106153 cites W2109651313 @default.
• W4328106153 cites W2118877866 @default.
• W4328106153 cites W2132548954 @default.
• W4328106153 cites W2134001789 @default.
• W4328106153 cites W2148585665 @default.
• W4328106153 cites W2470014202 @default.
• W4328106153 cites W2484348635 @default.
• W4328106153 cites W2741061140 @default.
• W4328106153 cites W2766619883 @default.
• W4328106153 cites W2800365842 @default.
• W4328106153 cites W2801222998 @default.
• W4328106153 cites W2922922923 @default.
• W4328106153 cites W2946248791 @default.
• W4328106153 cites W2947384380 @default.
• W4328106153 cites W3010832830 @default.
• W4328106153 cites W3012465309 @default.
• W4328106153 cites W3016851204 @default.
• W4328106153 cites W3080689315 @default.
• W4328106153 cites W3085511945 @default.
• W4328106153 cites W3111255098 @default.
• W4328106153 cites W3119134012 @default.
• W4328106153 cites W3122107095 @default.
• W4328106153 cites W3133277826 @default.
• W4328106153 cites W3141563773 @default.
• W4328106153 cites W3153169670 @default.
• W4328106153 cites W3158123298 @default.
• W4328106153 cites W3192840187 @default.
• W4328106153 cites W3199888972 @default.
• W4328106153 cites W3201177512 @default.
• W4328106153 cites W3210049956 @default.
• W4328106153 cites W4200020075 @default.
• W4328106153 cites W4200223265 @default.
• W4328106153 cites W4205170082 @default.
• W4328106153 cites W4225695315 @default.
• W4328106153 cites W4252758999 @default.
• W4328106153 cites W4285740729 @default.
• W4328106153 cites W4304842724 @default.
• W4328106153 doi "https://doi.org/10.3390/biom13030569" @default.
• W4328106153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36979504" @default.
• W4328106153 hasPublicationYear "2023" @default.
• W4328106153 type Work @default.
• W4328106153 citedByCount "0" @default.
• W4328106153 crossrefType "journal-article" @default.
• W4328106153 hasAuthorship W4328106153A5013505611 @default.
• W4328106153 hasAuthorship W4328106153A5014566953 @default.
• W4328106153 hasAuthorship W4328106153A5028411489 @default.
• W4328106153 hasAuthorship W4328106153A5034204612 @default.
• W4328106153 hasAuthorship W4328106153A5035417175 @default.
• W4328106153 hasAuthorship W4328106153A5038183095 @default.
• W4328106153 hasAuthorship W4328106153A5040899311 @default.
• W4328106153 hasAuthorship W4328106153A5047657357 @default.
• W4328106153 hasAuthorship W4328106153A5048534767 @default.
• W4328106153 hasAuthorship W4328106153A5051721256 @default.
• W4328106153 hasAuthorship W4328106153A5051855397 @default.
• W4328106153 hasAuthorship W4328106153A5067931661 @default.
• W4328106153 hasAuthorship W4328106153A5074248134 @default.
• W4328106153 hasAuthorship W4328106153A5081631386 @default.
• W4328106153 hasBestOaLocation W43281061531 @default.
• W4328106153 hasConcept C104317684 @default.
• W4328106153 hasConcept C116675565 @default.
• W4328106153 hasConcept C159047783 @default.
• W4328106153 hasConcept C159654299 @default.
• W4328106153 hasConcept C203014093 @default.
• W4328106153 hasConcept C22889606 @default.
• W4328106153 hasConcept C2778719978 @default.
• W4328106153 hasConcept C2779341262 @default.
• W4328106153 hasConcept C2780801004 @default.
• W4328106153 hasConcept C32611913 @default.

• next