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- W4356794 abstract "No AccessJournal of Urology1 Mar 1986Electron Microscopic Investigation of the Bladder Urothelium and Glycocalyx in Patients with Interstitial Cystitis J.S. Dixon, M. Holm-Bentzen, C.J. Gilpin, J.A. Gosling, E. Bostofte, T. Hald, and S. Larsen J.S. DixonJ.S. Dixon More articles by this author , M. Holm-BentzenM. Holm-Bentzen More articles by this author , C.J. GilpinC.J. Gilpin More articles by this author , J.A. GoslingJ.A. Gosling More articles by this author , E. BostofteE. Bostofte More articles by this author , T. HaldT. Hald More articles by this author , and S. LarsenS. Larsen More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)45763-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The electron microscopic appearance of the bladder urothelium and glycocalyx was investigated in ten patients with well defined interstitial cystitis and compared to the findings in ten control patients with stress incontinence as the only symptom. Ruthenium red, a polycationic dye which binds specifically to cell surface acid polysaccharides, was used to demonstrate the glycocalyx. In cases of interstitial cystitis two types of luminal cell were observed, each possessing a distinct surface glycocalyx. One type of cell possessed numerous plaques of asymmetric unit membrane associated with a relatively thin glycocalyx. The second type of cell was characterised by numerous microvilli and a relatively thick glycocalyx. In control material each type of cell and its associated glycocalyx was identified with similar frequency. Our study concludes that there are no differences in the morphologic appearances of the glycocalyx and of urothelial cells in patients with interstitial cystitis when compared with controls. Hence, the hypothesis that an important pathogenic factor in interstitial cystitis is a defective glycocalyx associated with a permeable urothelium, has not been supported. © 1986 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByYILMAZ U, LIU Y, ROTHMAN I, LEE J, YANG C and BERGER R (2018) INTRAVESICAL POTASSIUM CHLORIDE SENSITIVITY TEST IN MEN WITH CHRONIC PELVIC PAIN SYNDROMEJournal of Urology, VOL. 172, NO. 2, (548-550), Online publication date: 1-Aug-2004.ÇETINEL Ş, ERCAN F, ŞIRVANCI S, ŞEHIRLI Ö, ERSOY Y, ŞAN T and ŞENER G (2018) The Ameliorating Effect of Melatonin on Protamine Sulfate Induced Bladder Injury and its Relationship to Interstitial CystitisJournal of Urology, VOL. 169, NO. 4, (1564-1568), Online publication date: 1-Apr-2003.WEI D, POLITANO V, SELZER M and LOKESHWAR V (2018) THE ASSOCIATION OF ELEVATED URINARY TOTAL TO SULFATED GLYCOSAMINOGLYCAN RATIO AND HIGH MOLECULAR MASS HYALURONIC ACID WITH INTERSTITIAL CYSTITISJournal of Urology, VOL. 163, NO. 5, (1577-1583), Online publication date: 1-May-2000.ERICKSON D, SHEYKHNAZARI M, ORDILLE S and BHAVANANDAN V (2018) INCREASED URINARY HYALURONIC ACID AND INTERSTITIAL CYSTITISJournal of Urology, VOL. 160, NO. 4, (1282-1284), Online publication date: 1-Oct-1998.Wilson C, Leopard J, Nakamura R, Cheresh D, Stein P and Parsons C (2018) Selective Type IV Collagen Defects in the Urothelial Basement Membrane in Interstitial CystitisJournal of Urology, VOL. 154, NO. 3, (1222-1226), Online publication date: 1-Sep-1995.Moskowitz M, Byrne D, Callahan H, Parsons C, Valderrama E and Moldwin R (2018) Decreased Expression of a Glycoprotein Component of Bladder Surface Mucin (GP1) in Interstitial CystitisJournal of Urology, VOL. 151, NO. 2, (343-345), Online publication date: 1-Feb-1994.Chelsky M, Rosen S, Knight L, Maurer A, Hanno P and Ruggieri M (2018) Bladder Permeability in Interstitial Cystitis is Similar to That of Normal Volunteers: Direct Measurement by Transvesical Absorption of 99mtechnetium-Diethylenetriaminepentaacetic AcidJournal of Urology, VOL. 151, NO. 2, (346-349), Online publication date: 1-Feb-1994.Messing E (2018) Editorial: Interstitial CystitisJournal of Urology, VOL. 151, NO. 2, (355-356), Online publication date: 1-Feb-1994.Nickel J, Emerson L and Cornish J (2018) The Bladder Mucus (Glycosaminoglycan) Layer in Interstitial CystitisJournal of Urology, VOL. 149, NO. 4, (716-718), Online publication date: 1-Apr-1993.Hohenfellner M, Nunes L, Schmidt R, Lampel A, Thüroff J and Tanagho E (2018) Interstitial Cystitis: Increased Sympathetic Innervation and Related Neuropeptide SynthesisJournal of Urology, VOL. 147, NO. 3 Part 1, (587-591), Online publication date: 1-Mar-1992.Nielsen K, Kromann-Andersen B, Steven K and Hald T (2018) Failure of Combined Supratrigonal Cystectomy and Mainz Ileocecocystoplasty in Intractable Interstitial Cystitis: is Histology and Mast Cell Count a Reliable Predictor for the Outcome of Surgery?Journal of Urology, VOL. 144, NO. 2 Part 1, (255-258), Online publication date: 1-Aug-1990.Hanno P, Levin R, Monson F, Teuscher C, Zong Zhou Z, Ruggieri M, Whitmore K and Wein A (2018) Diagnosis of Interstitial CystitisJournal of Urology, VOL. 143, NO. 2, (278-281), Online publication date: 1-Feb-1990.Webster G and Maggio M (2018) The Management of Chronic Interstitial Cystitis by Substitution CystoplastyJournal of Urology, VOL. 141, NO. 2, (287-291), Online publication date: 1-Feb-1989.Fowler J, Lynes W, Lau J, Ghosh L and Mounzer A (2018) Interstitial Cystitis is Associated with Intraukothelial Tamm-Horsfall ProteinJournal of Urology, VOL. 140, NO. 6, (1385-1389), Online publication date: 1-Dec-1988.Holm-Bentzen M, Jacobsen F, Nerstrøm B, Lose G, Kristensen J, Pedersen R, Krarup T, Feggetter J, Bates P, Barnard R, Larsen S and Hald T (2018) A Prospective Double-Blind Clinically Controlled Multicenter Trial of Sodium Pentosanpolysulfate in the Treatment of Interstitial Cystitis and Related Painful Bladder DiseaseJournal of Urology, VOL. 138, NO. 3, (503-507), Online publication date: 1-Sep-1987.Mueller S, Thueroff J and Rumpelt H (2018) Urothelial Leukoplakia: New Aspects of Etiology and TherapyJournal of Urology, VOL. 137, NO. 5, (979-983), Online publication date: 1-May-1987. Volume 135Issue 3March 1986Page: 621-625 Advertisement Copyright & Permissions© 1986 by The American Urological Association Education and Research, Inc.MetricsAuthor Information J.S. Dixon More articles by this author M. Holm-Bentzen More articles by this author C.J. Gilpin More articles by this author J.A. Gosling More articles by this author E. Bostofte More articles by this author T. Hald More articles by this author S. Larsen More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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