Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361817246> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4361817246 abstract "<div>Abstract<p>Testicular germ cell tumors (TGCT) are the most frequently diagnosed solid tumors in young men ages 15 to 44 years. Embryonal carcinomas (EC) comprise a subset of TGCTs that exhibit pluripotent characteristics similar to embryonic stem (ES) cells, but the genetic drivers underlying malignant transformation of ECs are unknown. To elucidate the abnormal genetic events potentially contributing to TGCT malignancy, such as the existence of fusion genes or aberrant fusion transcript expression, we performed RNA sequencing of EC cell lines and their nonmalignant ES cell line counterparts. We identified eight novel fusion transcripts and one gene with alternative promoter usage, <i>ETV6</i>. Four out of nine transcripts were found recurrently expressed in an extended panel of primary TGCTs and additional EC cell lines, but not in normal parenchyma of the testis, implying tumor-specific expression. Two of the recurrent transcripts involved an intrachromosomal fusion between <i>RCC1</i> and <i>HENMT1</i> located 80 Mbp apart and an interchromosomal fusion between <i>RCC1</i> and <i>ABHD12B</i>. <i>RCC1-ABHD12B</i> and the <i>ETV6</i> transcript variant were found to be preferentially expressed in the more undifferentiated TGCT subtypes. <i>In vitro</i> differentiation of the NTERA2 EC cell line resulted in significantly reduced expression of both fusion transcripts involving <i>RCC1</i> and the <i>ETV6</i> transcript variant, indicating that they are markers of pluripotency in a malignant setting. In conclusion, we identified eight novel fusion transcripts that, to our knowledge, are the first fusion genes described in TGCT and may therefore potentially serve as genomic biomarkers of malignant progression. <i>Cancer Res; 76(1); 108–16. ©2015 AACR</i>.</p></div>" @default.
- W4361817246 created "2023-04-05" @default.
- W4361817246 creator A5022309106 @default.
- W4361817246 creator A5025715803 @default.
- W4361817246 creator A5028165423 @default.
- W4361817246 creator A5031360571 @default.
- W4361817246 creator A5061571221 @default.
- W4361817246 creator A5069996996 @default.
- W4361817246 creator A5089339700 @default.
- W4361817246 date "2023-03-30" @default.
- W4361817246 modified "2023-10-16" @default.
- W4361817246 title "Data from Identification of Novel Fusion Genes in Testicular Germ Cell Tumors" @default.
- W4361817246 doi "https://doi.org/10.1158/0008-5472.c.6507428.v1" @default.
- W4361817246 hasPublicationYear "2023" @default.
- W4361817246 type Work @default.
- W4361817246 citedByCount "0" @default.
- W4361817246 crossrefType "posted-content" @default.
- W4361817246 hasAuthorship W4361817246A5022309106 @default.
- W4361817246 hasAuthorship W4361817246A5025715803 @default.
- W4361817246 hasAuthorship W4361817246A5028165423 @default.
- W4361817246 hasAuthorship W4361817246A5031360571 @default.
- W4361817246 hasAuthorship W4361817246A5061571221 @default.
- W4361817246 hasAuthorship W4361817246A5069996996 @default.
- W4361817246 hasAuthorship W4361817246A5089339700 @default.
- W4361817246 hasConcept C104317684 @default.
- W4361817246 hasConcept C107459253 @default.
- W4361817246 hasConcept C111829193 @default.
- W4361817246 hasConcept C121608353 @default.
- W4361817246 hasConcept C138626823 @default.
- W4361817246 hasConcept C145103041 @default.
- W4361817246 hasConcept C153911025 @default.
- W4361817246 hasConcept C2776212926 @default.
- W4361817246 hasConcept C2780833115 @default.
- W4361817246 hasConcept C2911180711 @default.
- W4361817246 hasConcept C31033888 @default.
- W4361817246 hasConcept C41091548 @default.
- W4361817246 hasConcept C502942594 @default.
- W4361817246 hasConcept C54355233 @default.
- W4361817246 hasConcept C86803240 @default.
- W4361817246 hasConceptScore W4361817246C104317684 @default.
- W4361817246 hasConceptScore W4361817246C107459253 @default.
- W4361817246 hasConceptScore W4361817246C111829193 @default.
- W4361817246 hasConceptScore W4361817246C121608353 @default.
- W4361817246 hasConceptScore W4361817246C138626823 @default.
- W4361817246 hasConceptScore W4361817246C145103041 @default.
- W4361817246 hasConceptScore W4361817246C153911025 @default.
- W4361817246 hasConceptScore W4361817246C2776212926 @default.
- W4361817246 hasConceptScore W4361817246C2780833115 @default.
- W4361817246 hasConceptScore W4361817246C2911180711 @default.
- W4361817246 hasConceptScore W4361817246C31033888 @default.
- W4361817246 hasConceptScore W4361817246C41091548 @default.
- W4361817246 hasConceptScore W4361817246C502942594 @default.
- W4361817246 hasConceptScore W4361817246C54355233 @default.
- W4361817246 hasConceptScore W4361817246C86803240 @default.
- W4361817246 hasLocation W43618172461 @default.
- W4361817246 hasOpenAccess W4361817246 @default.
- W4361817246 hasPrimaryLocation W43618172461 @default.
- W4361817246 hasRelatedWork W141642606 @default.
- W4361817246 hasRelatedWork W1906899562 @default.
- W4361817246 hasRelatedWork W2002050195 @default.
- W4361817246 hasRelatedWork W2031366673 @default.
- W4361817246 hasRelatedWork W2123063573 @default.
- W4361817246 hasRelatedWork W2142679772 @default.
- W4361817246 hasRelatedWork W2151656460 @default.
- W4361817246 hasRelatedWork W4225413486 @default.
- W4361817246 hasRelatedWork W4321372702 @default.
- W4361817246 hasRelatedWork W4361817246 @default.
- W4361817246 isParatext "false" @default.
- W4361817246 isRetracted "false" @default.
- W4361817246 workType "article" @default.