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- W4366083956 abstract "Abstract Hypochlorous acid (HOCl) is critical for maintaining immune system balance, but it can harm mitochondria by hindering enzyme activity, leading to decreased ATP and increased cell death. In this study, we have designed a fluorophore with a pyridinium scaffold for selective staining of the mitochondria and to detect hypochlorite. The fluorophore exhibits strong solvatochromic emission due to intramolecular charge transfer and excellent sub‐cellular localization in the mitochondria. Additionally, it shows a rapid response to HOCl with high selectivity among different reactive oxygen/nitrogen compounds with a detection limit of 2.31 μM. Moreover, it is also utilized for the exogenous and endogenous detection of HOCl in live cells, which may help study the role of hypochlorite in organelles at the cellular level. DFT and TDDFT calculations have been carried out to understand the relationship between the structure and properties of the cationic probes with respect to the α‐cyano substitution and extension of π‐conjugation. The selective detection of HOCl by C4 over other cationic probes has also been well‐demonstrated, showing how the binding of HOCl affects the electronic properties of C4 through the analysis of non‐bonding orbitals (NBO) population, electrostatic potential surface (ESP), and density of states (DOS) projected DOS investigations." @default.
- W4366083956 created "2023-04-19" @default.
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- W4366083956 date "2023-06-28" @default.
- W4366083956 modified "2023-10-17" @default.
- W4366083956 title "Styryl‐NIR Mitochondrial Probes with Rapid HOCl Detection in Live‐Cells" @default.
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- W4366083956 doi "https://doi.org/10.1002/cbic.202300084" @default.
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