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- W4366191664 abstract "As part of tissue homeostasis, endothelial progenitors (EPCs) residing within the endothelium contribute to vascular maintenance and regeneration through self-renewal and differentiation. In various stem cell niche, macrophages (MΦ) help modulate progenitor stemness and behavior and have been reported to regulate blood vessel development and remodeling. Recently, subsets of perivascular macrophage (PVMΦ) were identified in the blood vessel vicinity during tissue homeostasis and wound healing. Nevertheless, the physiological role of these PVMΦ on EPC function in homeostasis and wound re-vascularisation remains elusive. In this study, we investigated the interaction and regulatory function of PVMΦ on EPCs’ stemness in the murine aorta and skin using an endothelial-specific lineage tracing model, Cdh5CreERT/Rosa-ZsGreen. Imaging flow cytometry analyses tracking remanent PVMΦ bodies on endothelial cells revealed that PVMΦ preferentially formed physical interaction with endothelial cells that displayed mesenchymal properties in the healthy aorta (18.81% ± 13.13%) and skin (10.02% ± 0.92%). In situ characterization showed that the F4/80+Lyve1+ PVMΦ were in the adventitial area of the aorta, and resided within the lower dermis of the dorsal skin. MΦ depletion using clodronate liposomes doubled aorta EPC proportion (p=0.0079) in vivo, where it displayed increased proliferative potential with reduced clonogenic capacity in vitro. Functionally, attenuating macrophage-derived Wnt activity using Wlsfl/flLysM-Cre mice elevated EPC cell number by two-fold on day 5 post cutaneous injury without affecting other endothelial subpopulations. Overall, our data indicate that PVMΦ constitute part of the vascular niche by regulating EPCs’ quiescence and self-renewal, potentially via paracrine Wnt signaling." @default.
- W4366191664 created "2023-04-19" @default.
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- W4366191664 date "2023-05-01" @default.
- W4366191664 modified "2023-09-28" @default.
- W4366191664 title "1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling" @default.
- W4366191664 doi "https://doi.org/10.1016/j.jid.2023.03.1528" @default.
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