FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366572649> ?p ?o ?g. }

• W4366572649 abstract "Abstract The “noisy signal” hypothesis of basal ganglia dysfunction in Parkinson’s disease suggests that major motor symptoms of the disorder are caused by the development of abnormal basal ganglia activity patterns resulting in the propagation of “noisy” signals to target systems. While such abnormal activity patterns might be useful biomarkers for the development of therapeutic interventions, correlation between specific changes in activity and Parkinson’s disease symptoms has been inconsistently demonstrated, and raises questions concerning the accuracy of the hypothesis. Here, we tested this hypothesis by considering three nodes of the basal ganglia network, the subthalamus, globus pallidus interna and cortex during self-paced and cued movements in patients with Parkinson’s disease. Interactions between these regions were analyzed using measures that assess both linear and non-linear relationships. Marked changes in the network are observed with dopamine state. Specifically, we detected functional disconnection of the basal ganglia from the cortex and higher network variability in untreated Parkinson’s disease, but various patterns of directed functional connectivity with lower network variability in treated Parkinson’s disease. When we examine the system output, significant correlation is observed between variability in the cortico-basal ganglia network and muscle activity variability but only in the treated state. Rather than supporting a role of the basal ganglia in the transmission of noisy signals in patients with Parkinson’s disease, these findings suggest that cortico-basal ganglia network interactions by fault or design, in the treated Parkinsonian state, are actually associated with improved cortical network output variability." @default.
• W4366572649 created "2023-04-22" @default.
• W4366572649 creator A5003754626 @default.
• W4366572649 date "2023-04-13" @default.
• W4366572649 modified "2023-10-14" @default.
• W4366572649 title "Basal ganglia functional connectivity network analysis does not support the “noisy signal” hypothesis of Parkinson’s disease" @default.
• W4366572649 cites W118472675 @default.
• W4366572649 cites W1593738801 @default.
• W4366572649 cites W175236080 @default.
• W4366572649 cites W1768450208 @default.
• W4366572649 cites W1971283363 @default.
• W4366572649 cites W1989605251 @default.
• W4366572649 cites W1992359588 @default.
• W4366572649 cites W1998467756 @default.
• W4366572649 cites W2012265506 @default.
• W4366572649 cites W2016696802 @default.
• W4366572649 cites W2018822471 @default.
• W4366572649 cites W2024943800 @default.
• W4366572649 cites W2025026150 @default.
• W4366572649 cites W2034623206 @default.
• W4366572649 cites W2035819830 @default.
• W4366572649 cites W2035972257 @default.
• W4366572649 cites W2050540607 @default.
• W4366572649 cites W2054102932 @default.
• W4366572649 cites W2060588252 @default.
• W4366572649 cites W2087384202 @default.
• W4366572649 cites W2092310746 @default.
• W4366572649 cites W2096875305 @default.
• W4366572649 cites W2108367194 @default.
• W4366572649 cites W2109170458 @default.
• W4366572649 cites W2109765029 @default.
• W4366572649 cites W2111443698 @default.
• W4366572649 cites W2111893944 @default.
• W4366572649 cites W2117823584 @default.
• W4366572649 cites W2122422488 @default.
• W4366572649 cites W2123208606 @default.
• W4366572649 cites W2124935025 @default.
• W4366572649 cites W2129643089 @default.
• W4366572649 cites W2130529454 @default.
• W4366572649 cites W2136989584 @default.
• W4366572649 cites W2141405085 @default.
• W4366572649 cites W2145590292 @default.
• W4366572649 cites W2156179625 @default.
• W4366572649 cites W2166394603 @default.
• W4366572649 cites W2167683893 @default.
• W4366572649 cites W2171030528 @default.
• W4366572649 cites W21769058 @default.
• W4366572649 cites W2186321983 @default.
• W4366572649 cites W2222445509 @default.
• W4366572649 cites W2507130521 @default.
• W4366572649 cites W2537231786 @default.
• W4366572649 cites W2613454693 @default.
• W4366572649 cites W2739497102 @default.
• W4366572649 cites W2752167926 @default.
• W4366572649 cites W2771883945 @default.
• W4366572649 cites W2883628765 @default.
• W4366572649 cites W2915370500 @default.
• W4366572649 cites W2924709016 @default.
• W4366572649 cites W2949791819 @default.
• W4366572649 cites W2954946396 @default.
• W4366572649 cites W2963756333 @default.
• W4366572649 cites W2974838036 @default.
• W4366572649 cites W2996840563 @default.
• W4366572649 cites W3003628688 @default.
• W4366572649 cites W3018283614 @default.
• W4366572649 cites W4280492262 @default.
• W4366572649 doi "https://doi.org/10.1093/braincomms/fcad123" @default.
• W4366572649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37124947" @default.
• W4366572649 hasPublicationYear "2023" @default.
• W4366572649 type Work @default.
• W4366572649 citedByCount "0" @default.
• W4366572649 crossrefType "journal-article" @default.
• W4366572649 hasAuthorship W4366572649A5003754626 @default.
• W4366572649 hasBestOaLocation W43665726491 @default.
• W4366572649 hasConcept C142724271 @default.
• W4366572649 hasConcept C15744967 @default.
• W4366572649 hasConcept C162536842 @default.
• W4366572649 hasConcept C169760540 @default.
• W4366572649 hasConcept C2778187257 @default.
• W4366572649 hasConcept C2779134260 @default.
• W4366572649 hasConcept C2779734285 @default.
• W4366572649 hasConcept C2780278869 @default.
• W4366572649 hasConcept C513476851 @default.
• W4366572649 hasConcept C529278444 @default.
• W4366572649 hasConcept C71924100 @default.
• W4366572649 hasConcept C86803240 @default.
• W4366572649 hasConceptScore W4366572649C142724271 @default.
• W4366572649 hasConceptScore W4366572649C15744967 @default.
• W4366572649 hasConceptScore W4366572649C162536842 @default.
• W4366572649 hasConceptScore W4366572649C169760540 @default.
• W4366572649 hasConceptScore W4366572649C2778187257 @default.
• W4366572649 hasConceptScore W4366572649C2779134260 @default.
• W4366572649 hasConceptScore W4366572649C2779734285 @default.
• W4366572649 hasConceptScore W4366572649C2780278869 @default.
• W4366572649 hasConceptScore W4366572649C513476851 @default.
• W4366572649 hasConceptScore W4366572649C529278444 @default.
• W4366572649 hasConceptScore W4366572649C71924100 @default.
• W4366572649 hasConceptScore W4366572649C86803240 @default.
• W4366572649 hasLocation W43665726491 @default.
• W4366572649 hasLocation W43665726492 @default.

• next