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• W4376226257 abstract "The objective of this study was to investigate the effects of dietary metabolizable energy (ME) level and the ratio of linoleic acid:α-linolenic acid (LA:ALA) on the growth performance, lipid metabolism, circulatory and joint inflammatory status, and synovial fluid proteome of grow-finish pigs. A total of 224 pigs (BW = 41.5 ± 6.1 kg; PIC Genus 337 × 1050, Hendersonville, TN) were randomly assigned to either a high (3.55 Mcal/kg; HE) or low (3.29 Mcal/kg; LE) ME dietary treatment with a high (23:1) or low (12:1) LA:ALA in a 2 × 2 factorial arrangement. Diets were fed across three 28-d phases. Pigs were housed either four barrows or four gilts per pen. Blood samples were collected on days 0, 21, 42, and 84. Synovial fluid was collected from the hock and carpus joints on days 0 and 84. Liver and adipose tissue samples were collected on day 84. Data were analyzed as repeated measures using PROC MIXED (SAS 9.4) with pen as the experimental unit and energy level, essential fatty acid ratio, sex, phase, and their interactions as fixed effects. Compared to LE, HE increased days 28, 56, and 84 body weight (BW; P = 0.005). For the overall period, HE increased average daily gain (ADG) compared to LE (P < 0.001) and improved feed efficiency (P = 0.001), while LE increased feed intake compared to HE (P < 0.001). Gilts receiving diets with low LA:ALA had similar final BW to barrows receiving a low LA:ALA at days 28, 56, and 84 (P = 0.024), resulting from improved overall days 0-84 ADG compared to gilts receiving the high LA:ALA (P = 0.031). In the liver, HE decreased the mRNA abundance of acetyl CoA carboxylase (ACACA; P = 0.004), cluster of differentiation 36 (P = 0.034), and tended to decrease fatty acid synthase (FASN; P = 0.056). In adipose tissue, HE decreased ACACA (P = 0.001) and FASN (P = 0.017). Plasma inflammatory markers C-reactive protein (CRP) and tumor necrosis factor-α (TNFα) were reduced on day 84 compared to day 0 (P ≤ 0.014). In the hock and carpus synovial fluid, LE tended to reduce CRP and TNFα (P ≤ 0.096). Hock and carpus synovial fluid CRP were also reduced on day 84 compared to day 0 (P = 0.001). Age of the pig impacted serum and hock synovial fluid protein abundance, but not energy level, LA:ALA, or their interactions (P < 0.05). To conclude, the high and low LA:ALA ratios utilized in this study can be fed at varying energy levels without impacting growth. Additionally, LA:ALA ratios can differentially impact the growth of barrows and gilts.In pig diets, it has been established that added fat can improve growth and feed efficiency; however, insufficient research has been reported evaluating specific essential fatty acids found in commonly available fat sources. Essential fatty acids are important in several biological functions in the body, including growth, inflammation, and immune function. Given shared metabolism between essential fatty acids linoleic acid and α-linolenic acid, it has been suggested that their dietary ratio is critical to balance inflammatory responses. In the present research, a 12:1 dietary linoleic:linolenic acid ratio improved gilt, but not barrow, daily gain and did not impact inflammation. Pro-inflammatory responses were reduced over time, both in the blood and joint fluid. High-fat diets also improved growth performance, suppressed genes involved in fatty acid synthesis, and tended to increase joint inflammation. There was no interaction between dietary fat level and essential fatty acid ratio for any variable. Overall, dietary essential fatty acid ratios impact the growth of gilts, regardless of dietary fat inclusion, with no apparent effects on inflammation." @default.
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• W4376226257 date "2023-01-01" @default.
• W4376226257 modified "2023-09-30" @default.
• W4376226257 title "The effects of dietary essential fatty acid ratios and energy level on growth performance, lipid metabolism, and inflammation in grow-finish pigs" @default.
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• W4376226257 doi "https://doi.org/10.1093/jas/skad151" @default.
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