Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011320> ?p ?o ?g. }
- W4377011320 endingPage "15" @default.
- W4377011320 startingPage "1" @default.
- W4377011320 abstract "Available anti-leishmanial drugs are associated with toxic side effects, necessitating the search for safe and effective alternatives. This study is focused on identifying traditional medicinal plant natural products for anti-leishmanial potential and possible mechanism of action. Compounds S and T. cordifolia residual fraction (TC-5) presented the best anti-leishmanial activity (IC50: 0.446 and 1.028 mg/ml) against promastigotes at 48 h and less cytotoxicity to THP-1 macrophages. These test agents elicited increased expression of pro-inflammatory cytokines; TNFα and IL-12. In infected untreated macrophages, NO release was suppressed but was significantly (p < 0.05) increased in infected cells treated with compound S. Importantly, Compound S was found to interact with LdTopoIIdimer in silico, resulting in a likely reduced ability of nucleic acid (dsDNA)-remodelling and, as a result, parasite proliferation in vitro. Thereby, Compound S possesses anti-leishmanial activity and this effect occurs via a Th1-mediated pro-inflammatory response. An increase in NO release and its inhibitory effect on LdTopoII may also contribute to the anti-leishmanial effect of compound S. These results show the potential of this compound as a potential starting point for the discovery of novel anti-leishmanial leads.Communicated by Ramaswamy H. Sarma" @default.
- W4377011320 created "2023-05-19" @default.
- W4377011320 creator A5000983076 @default.
- W4377011320 creator A5020310909 @default.
- W4377011320 creator A5021515434 @default.
- W4377011320 creator A5035990735 @default.
- W4377011320 creator A5036075038 @default.
- W4377011320 creator A5048210305 @default.
- W4377011320 creator A5050614034 @default.
- W4377011320 creator A5069082684 @default.
- W4377011320 creator A5077852448 @default.
- W4377011320 creator A5080419497 @default.
- W4377011320 date "2023-05-18" @default.
- W4377011320 modified "2023-09-27" @default.
- W4377011320 title "Screening of traditional medicinal plant extracts and compounds identifies a potent anti-leishmanial diarylheptanoid from <i>Siphonochilus aethiopicus</i>" @default.
- W4377011320 cites W1546896179 @default.
- W4377011320 cites W1549911162 @default.
- W4377011320 cites W1603633005 @default.
- W4377011320 cites W1611522350 @default.
- W4377011320 cites W1965694039 @default.
- W4377011320 cites W1975687767 @default.
- W4377011320 cites W1976122793 @default.
- W4377011320 cites W1986191025 @default.
- W4377011320 cites W1988522026 @default.
- W4377011320 cites W1999650975 @default.
- W4377011320 cites W2002204067 @default.
- W4377011320 cites W2002918129 @default.
- W4377011320 cites W2008045382 @default.
- W4377011320 cites W2013452258 @default.
- W4377011320 cites W2017138772 @default.
- W4377011320 cites W2038425317 @default.
- W4377011320 cites W2038689279 @default.
- W4377011320 cites W2043290296 @default.
- W4377011320 cites W2059118242 @default.
- W4377011320 cites W2061136308 @default.
- W4377011320 cites W2069419592 @default.
- W4377011320 cites W2071390504 @default.
- W4377011320 cites W2072398182 @default.
- W4377011320 cites W2073555176 @default.
- W4377011320 cites W2078321100 @default.
- W4377011320 cites W2096560421 @default.
- W4377011320 cites W2106684817 @default.
- W4377011320 cites W2108168886 @default.
- W4377011320 cites W2122386753 @default.
- W4377011320 cites W2129418158 @default.
- W4377011320 cites W2132312856 @default.
- W4377011320 cites W2139915497 @default.
- W4377011320 cites W2141589119 @default.
- W4377011320 cites W2293039793 @default.
- W4377011320 cites W2522530396 @default.
- W4377011320 cites W2528863043 @default.
- W4377011320 cites W2550023859 @default.
- W4377011320 cites W2767976488 @default.
- W4377011320 cites W2784251809 @default.
- W4377011320 cites W2802383752 @default.
- W4377011320 cites W2802695578 @default.
- W4377011320 cites W2804822363 @default.
- W4377011320 cites W2808544257 @default.
- W4377011320 cites W2885992037 @default.
- W4377011320 cites W2892083369 @default.
- W4377011320 cites W2903523683 @default.
- W4377011320 cites W2929944850 @default.
- W4377011320 cites W2941537534 @default.
- W4377011320 cites W2987783202 @default.
- W4377011320 cites W2991049655 @default.
- W4377011320 cites W3007142329 @default.
- W4377011320 cites W3025529754 @default.
- W4377011320 cites W3045174859 @default.
- W4377011320 cites W3092077289 @default.
- W4377011320 cites W3208696114 @default.
- W4377011320 cites W4282011232 @default.
- W4377011320 cites W858975635 @default.
- W4377011320 doi "https://doi.org/10.1080/07391102.2023.2212779" @default.
- W4377011320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199276" @default.
- W4377011320 hasPublicationYear "2023" @default.
- W4377011320 type Work @default.
- W4377011320 citedByCount "1" @default.
- W4377011320 countsByYear W43770113202023 @default.
- W4377011320 crossrefType "journal-article" @default.
- W4377011320 hasAuthorship W4377011320A5000983076 @default.
- W4377011320 hasAuthorship W4377011320A5020310909 @default.
- W4377011320 hasAuthorship W4377011320A5021515434 @default.
- W4377011320 hasAuthorship W4377011320A5035990735 @default.
- W4377011320 hasAuthorship W4377011320A5036075038 @default.
- W4377011320 hasAuthorship W4377011320A5048210305 @default.
- W4377011320 hasAuthorship W4377011320A5050614034 @default.
- W4377011320 hasAuthorship W4377011320A5069082684 @default.
- W4377011320 hasAuthorship W4377011320A5077852448 @default.
- W4377011320 hasAuthorship W4377011320A5080419497 @default.
- W4377011320 hasConcept C104317684 @default.
- W4377011320 hasConcept C109316439 @default.
- W4377011320 hasConcept C185592680 @default.
- W4377011320 hasConcept C202751555 @default.
- W4377011320 hasConcept C24107716 @default.
- W4377011320 hasConcept C2775905019 @default.
- W4377011320 hasConcept C2777752497 @default.
- W4377011320 hasConcept C2779703632 @default.
- W4377011320 hasConcept C55493867 @default.