Matches in SemOpenAlex for { <https://semopenalex.org/work/W4380423022> ?p ?o ?g. }
- W4380423022 abstract "Abstract Background Opportunities for adjunct therapies with cooling in neonatal encephalopathy are imminent; however, robust biomarkers of early assessment are lacking. Using an optical platform of broadband near-infrared spectroscopy and diffuse correlation spectroscopy to directly measure mitochondrial metabolism (oxCCO), oxygenation (HbD), cerebral blood flow (CBF), we hypothesised optical indices early (1-h post insult) after hypoxia-ischaemia (HI) predicts insult severity and outcome. Methods Nineteen newborn large white piglets underwent continuous neuromonitoring as controls or following moderate or severe HI. Optical indices were expressed as mean semblance (phase difference) and coherence (spectral similarity) between signals using wavelet analysis. Outcome markers included the lactate/N-acetyl aspartate (Lac/NAA) ratio at 6 h on proton MRS and TUNEL cell count. Results CBF-HbD semblance (cerebrovascular dysfunction) correlated with BGT and white matter (WM) Lac/NAA ( r 2 = 0.46, p = 0.004, r 2 = 0.45, p = 0.004, respectively), TUNEL cell count ( r 2 = 0.34, p = 0.02) and predicted both initial insult ( r 2 = 0.62, p = 0.002) and outcome group ( r 2 = 0.65 p = 0.003). oxCCO-HbD semblance (cerebral metabolic dysfunction) correlated with BGT and WM Lac/NAA ( r 2 = 0.34, p = 0.01 and r 2 = 0.46, p = 0.002, respectively) and differentiated between outcome groups ( r 2 = 0.43, p = 0.01). Conclusion Optical markers of both cerebral metabolic and vascular dysfunction 1 h after HI predicted injury severity and subsequent outcome in a pre-clinical model. Impact This study highlights the possibility of using non-invasive optical biomarkers for early assessment of injury severity following neonatal encephalopathy, relating to the outcome. Continuous cot-side monitoring of these optical markers can be useful for disease stratification in the clinical population and for identifying infants who might benefit from future adjunct neuroprotective therapies beyond cooling." @default.
- W4380423022 created "2023-06-14" @default.
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- W4380423022 date "2023-06-13" @default.
- W4380423022 modified "2023-10-17" @default.
- W4380423022 title "Early assessment of injury with optical markers in a piglet model of neonatal encephalopathy" @default.
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- W4380423022 doi "https://doi.org/10.1038/s41390-023-02679-y" @default.
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