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• W4381617355 endingPage "1029" @default.
• W4381617355 startingPage "1029" @default.
• W4381617355 abstract "During the course of Crohn’s disease, the response of mesenteric adipose tissue to the production of inflammatory mediators and bacterial invasion through the intestinal mucosa results in the formation of creeping fat. Creeping fat describes the arresting finger-like projections that surround the inflamed bowel. In this review, the microscopic and macroscopic features of creeping fat and histological evidence for the importance of this tissue are discussed. Moreover, the most recent insights into the radiological assessment of creeping fat in patients with Crohn’s disease are reported. Advances in imaging techniques have revolutionized the possibility of visualization and quantification of adipose tissue depots with excellent accuracy. Visceral fat has been significantly correlated with various Crohn’s-disease-related outcomes. Despite the difficulties in distinguishing physiologic perienteric fat from creeping fat, the growing interest in fat-wrapping in Crohn’s disease has rejuvenated radiologic research. With regard to the noninvasive fat-wrapping assessment, a novel CT enterography-based mesenteric creeping fat index has been developed for the mitigation of the confounding effect of normal retroperitoneal and perienteric adipose tissue. Research on machine learning algorithms and computational radiomics in conjunction with mechanistic studies may be the key for the elucidation of the complex role of creeping fat in Crohn’s disease." @default.
• W4381617355 created "2023-06-23" @default.
• W4381617355 creator A5005573519 @default.
• W4381617355 creator A5008950143 @default.
• W4381617355 creator A5039063266 @default.
• W4381617355 creator A5056970878 @default.
• W4381617355 date "2023-06-21" @default.
• W4381617355 modified "2023-09-30" @default.
• W4381617355 title "Creeping Fat in Crohn’s Disease—Surgical, Histological, and Radiological Approaches" @default.
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