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- W4382011434 abstract "Objective To assess the prognostic role of pretreatment lymphocyte percentage (LY%) for patients with oral squamous cell carcinoma (OSCC). Methods A large-scale prospective cohort study between July 2002 and March 2021 was conducted. Propensity score-matched (PSM) analysis and inverse probability of treatment weighting (IPTW) analysis were performed to adjust for potential confounders. Using random survival forest (RSF), the relative importance of pretreatment LY% in prognosis prediction was also assessed. Results A total of 743 patients were enrolled and followed up (median: 2.75 years, interquartile range: 1.25–4.42 years). A high pretreatment LY% was significantly associated with better disease-specific survival of patients with OSCC (Hazard ratio [HR] = 0.60, 95% confidence interval [CI]: 0.42, 0.84). The same tendency was observed in PSM (HR = 0.57, 95% CI: 0.38, 0.85) and IPTW analysis (HR = 0.57, 95% CI: 0.40, 0.82). RSF showed that LY% ranked the fifth among importance ranking of all prognostic factors. Conclusion Pretreatment LY% showed a moderate predictive ability, suggesting it might be a valuable tool to predict prognosis for patients with OSCC." @default.
- W4382011434 created "2023-06-27" @default.
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- W4382011434 date "2023-06-25" @default.
- W4382011434 modified "2023-09-25" @default.
- W4382011434 title "Prognostic value of pretreatment lymphocyte percentage in oral cancer: A prospective cohort study" @default.
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- W4382011434 doi "https://doi.org/10.1111/odi.14658" @default.
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