Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382810814> ?p ?o ?g. }
- W4382810814 endingPage "104725" @default.
- W4382810814 startingPage "104725" @default.
- W4382810814 abstract "Finasteride, a selective Type II 5α-reductase inhibitor, has been approved as an oral drug for the treatment and prevention of androgenetic alopecia (AGA). The daily administration of finasteride by oral route may lead to various undesirable systemic side effects. In the present study, finasteride niosomes (FIN-NIS) as a dermal topical delivery system were developed evaluated in vitro/in vivo in an attempt to overcome the limitations of the oral administration of finasteride, enhance the retention of finasteride into hair follicles, and cause fewer adverse effects. FIN-NIS were prepared by ethanol injection method and characterized for particle size, entrapment efficiency (EE), in vitro release and in vitro skin retention. Testosterone-induced AGA mice model was used to evaluate the therapeutic effect of FIN-NIS. The results show that the particle size of FIN-NIS was about 260 nm with a good loading capacity, and the EE was greater than 90%. FIN-NIS had the sustained-release effect to some extent. Compared with the hydroethanolic solution of finasteride (FIN-hydroethanol) and finasteride suspension (FIN-suspension), FIN-NIS showed higher drug concentration in the excised rat skin, especially in the hair follicle area. The drug accumulation of FIN-NIS in the hair follicles was 20 times higher than that of FIN-hydroalcohol. In addition, FIN-NIS was more effective to promote hair regeneration in AGA mice than FIN-suspension, and the effectiveness of FIN-NIS even exceeded that of minoxidil. In conclusion, FIN-NIS could become a promising dermal topical delivery system for enhancing the performance of finasteride for the management of AGA and avoiding the possible risk of systemic side effects associated with oral administration." @default.
- W4382810814 created "2023-07-02" @default.
- W4382810814 creator A5003614330 @default.
- W4382810814 creator A5009795051 @default.
- W4382810814 creator A5011100608 @default.
- W4382810814 creator A5015143203 @default.
- W4382810814 creator A5023235352 @default.
- W4382810814 creator A5031815299 @default.
- W4382810814 creator A5048279362 @default.
- W4382810814 creator A5061511537 @default.
- W4382810814 creator A5079789406 @default.
- W4382810814 date "2023-09-01" @default.
- W4382810814 modified "2023-10-02" @default.
- W4382810814 title "Development and evaluation of finasteride niosomes targeting to hair follicles for the management of androgenic alopecia" @default.
- W4382810814 cites W1568186097 @default.
- W4382810814 cites W1973231585 @default.
- W4382810814 cites W1975970944 @default.
- W4382810814 cites W2003773638 @default.
- W4382810814 cites W2015278347 @default.
- W4382810814 cites W2028861639 @default.
- W4382810814 cites W2042253098 @default.
- W4382810814 cites W2085208724 @default.
- W4382810814 cites W2118213449 @default.
- W4382810814 cites W2297539117 @default.
- W4382810814 cites W2329170157 @default.
- W4382810814 cites W2518616976 @default.
- W4382810814 cites W2597986029 @default.
- W4382810814 cites W2725877313 @default.
- W4382810814 cites W2753876034 @default.
- W4382810814 cites W2756180724 @default.
- W4382810814 cites W2785247964 @default.
- W4382810814 cites W2790816372 @default.
- W4382810814 cites W2884856317 @default.
- W4382810814 cites W2895383710 @default.
- W4382810814 cites W2923845314 @default.
- W4382810814 cites W2969296462 @default.
- W4382810814 cites W2985517886 @default.
- W4382810814 cites W2995727455 @default.
- W4382810814 cites W3004238698 @default.
- W4382810814 cites W3007628315 @default.
- W4382810814 cites W3015733434 @default.
- W4382810814 cites W3031033669 @default.
- W4382810814 cites W3034775714 @default.
- W4382810814 cites W3036547471 @default.
- W4382810814 cites W3045656631 @default.
- W4382810814 cites W3088133313 @default.
- W4382810814 cites W3110146416 @default.
- W4382810814 cites W3131254892 @default.
- W4382810814 cites W3131913208 @default.
- W4382810814 cites W3133017794 @default.
- W4382810814 cites W3156171009 @default.
- W4382810814 cites W3156561585 @default.
- W4382810814 cites W3207776435 @default.
- W4382810814 cites W4220867756 @default.
- W4382810814 cites W4221010033 @default.
- W4382810814 cites W4243326970 @default.
- W4382810814 cites W854625900 @default.
- W4382810814 doi "https://doi.org/10.1016/j.jddst.2023.104725" @default.
- W4382810814 hasPublicationYear "2023" @default.
- W4382810814 type Work @default.
- W4382810814 citedByCount "0" @default.
- W4382810814 crossrefType "journal-article" @default.
- W4382810814 hasAuthorship W4382810814A5003614330 @default.
- W4382810814 hasAuthorship W4382810814A5009795051 @default.
- W4382810814 hasAuthorship W4382810814A5011100608 @default.
- W4382810814 hasAuthorship W4382810814A5015143203 @default.
- W4382810814 hasAuthorship W4382810814A5023235352 @default.
- W4382810814 hasAuthorship W4382810814A5031815299 @default.
- W4382810814 hasAuthorship W4382810814A5048279362 @default.
- W4382810814 hasAuthorship W4382810814A5061511537 @default.
- W4382810814 hasAuthorship W4382810814A5079789406 @default.
- W4382810814 hasConcept C121608353 @default.
- W4382810814 hasConcept C126322002 @default.
- W4382810814 hasConcept C130316041 @default.
- W4382810814 hasConcept C134018914 @default.
- W4382810814 hasConcept C16005928 @default.
- W4382810814 hasConcept C178790620 @default.
- W4382810814 hasConcept C185592680 @default.
- W4382810814 hasConcept C199360897 @default.
- W4382810814 hasConcept C2775874879 @default.
- W4382810814 hasConcept C2776235491 @default.
- W4382810814 hasConcept C2776360568 @default.
- W4382810814 hasConcept C2777056448 @default.
- W4382810814 hasConcept C2779279991 @default.
- W4382810814 hasConcept C2779820397 @default.
- W4382810814 hasConcept C2909935303 @default.
- W4382810814 hasConcept C2911091166 @default.
- W4382810814 hasConcept C3454156 @default.
- W4382810814 hasConcept C41008148 @default.
- W4382810814 hasConcept C41625074 @default.
- W4382810814 hasConcept C55493867 @default.
- W4382810814 hasConcept C71924100 @default.
- W4382810814 hasConcept C72918618 @default.
- W4382810814 hasConcept C98274493 @default.
- W4382810814 hasConceptScore W4382810814C121608353 @default.
- W4382810814 hasConceptScore W4382810814C126322002 @default.
- W4382810814 hasConceptScore W4382810814C130316041 @default.
- W4382810814 hasConceptScore W4382810814C134018914 @default.