Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383483598> ?p ?o ?g. }
- W4383483598 endingPage "e17119" @default.
- W4383483598 startingPage "e17119" @default.
- W4383483598 abstract "Cell mediated immune escape, a microenvironment factor, induces tumorigenesis and metastasis. The purpose of this study was to display the characteristics of T cell populations in immune microenvironments for colorectal cancer (CRC) metastasis. Unsupervised cluster analysis was conducted to identify functionally distinct T cell clusters from 3,003 cells in peripheral blood and 4,656 cells in tissues. Subsequently, a total of 8 and 4 distinct T cell population clusters were identified from tumor tissue and peripheral blood, respectively. High levels of CD8+TEX, CD4+TRM, TH1-like T cells, CD8+TEM, tumor-Treg from tissues, and CD4+TN from peripheral blood are essential components of immune microenvironment for the prediction of CRC metastasis. Moreover, exhausted T cells are characterized by higher expression of multiple inhibitory receptors, including PDCD1 and LAG3. Some genes such as PFKFB3, GNLY, circDCUN1D4, TXNIP and NR4A2 in T cells of cluster were statistically different between CRC metastasis and non-metastasis. The ligand-receptor interactions identified between different cluster cells and metastases-related DEGs identified from each cluster revealed that the communications of cells, alterations of functions, and numbers of T subsets may contribute to the metastasis of CRC. The mutation frequency of KiAA1551, ATP8B4 and LNPEP in T cells from tissues and SOR1 from peripheral blood were higher in metastatic CRC than that in non-metastatic CRC. In conclusion, the discovery of differential genes in T cells may provide potential targets for immunotherapy of CRC metastasis and relevant insights into the clinical prediction and prognosis of CRC metastasis." @default.
- W4383483598 created "2023-07-08" @default.
- W4383483598 creator A5006541554 @default.
- W4383483598 creator A5011219441 @default.
- W4383483598 creator A5015027082 @default.
- W4383483598 creator A5016173294 @default.
- W4383483598 creator A5030182006 @default.
- W4383483598 creator A5034994816 @default.
- W4383483598 creator A5067221645 @default.
- W4383483598 creator A5076961188 @default.
- W4383483598 creator A5079700843 @default.
- W4383483598 creator A5080990304 @default.
- W4383483598 date "2023-07-01" @default.
- W4383483598 modified "2023-10-14" @default.
- W4383483598 title "Single-cell transcriptome analysis reveals T population heterogeneity and functions in tumor microenvironment of colorectal cancer metastases" @default.
- W4383483598 cites W1940241680 @default.
- W4383483598 cites W1973020652 @default.
- W4383483598 cites W1974423469 @default.
- W4383483598 cites W2009854316 @default.
- W4383483598 cites W2020406481 @default.
- W4383483598 cites W2027609828 @default.
- W4383483598 cites W2033278321 @default.
- W4383483598 cites W2040812157 @default.
- W4383483598 cites W2045362868 @default.
- W4383483598 cites W2096151993 @default.
- W4383483598 cites W2104347254 @default.
- W4383483598 cites W2117647921 @default.
- W4383483598 cites W2124805659 @default.
- W4383483598 cites W2125245877 @default.
- W4383483598 cites W2142300779 @default.
- W4383483598 cites W2160143217 @default.
- W4383483598 cites W2163485494 @default.
- W4383483598 cites W2171775390 @default.
- W4383483598 cites W2230320310 @default.
- W4383483598 cites W2343931737 @default.
- W4383483598 cites W2431784366 @default.
- W4383483598 cites W2556868315 @default.
- W4383483598 cites W2557833574 @default.
- W4383483598 cites W2558534012 @default.
- W4383483598 cites W2570448866 @default.
- W4383483598 cites W2571903415 @default.
- W4383483598 cites W2572174216 @default.
- W4383483598 cites W2577648550 @default.
- W4383483598 cites W2605505042 @default.
- W4383483598 cites W2620044097 @default.
- W4383483598 cites W2625185605 @default.
- W4383483598 cites W2742865544 @default.
- W4383483598 cites W2746288782 @default.
- W4383483598 cites W2774264760 @default.
- W4383483598 cites W2783494975 @default.
- W4383483598 cites W2808837841 @default.
- W4383483598 cites W2883725514 @default.
- W4383483598 cites W2889646458 @default.
- W4383483598 cites W2896872272 @default.
- W4383483598 cites W2897087760 @default.
- W4383483598 cites W2898120081 @default.
- W4383483598 cites W2902655481 @default.
- W4383483598 cites W2904068706 @default.
- W4383483598 cites W2907783748 @default.
- W4383483598 cites W2909809653 @default.
- W4383483598 cites W2914435722 @default.
- W4383483598 cites W2928665623 @default.
- W4383483598 cites W2938897571 @default.
- W4383483598 cites W2942515595 @default.
- W4383483598 cites W2943013004 @default.
- W4383483598 cites W2944013210 @default.
- W4383483598 cites W2946276219 @default.
- W4383483598 cites W2991061300 @default.
- W4383483598 cites W2999263395 @default.
- W4383483598 cites W3030888252 @default.
- W4383483598 cites W3032968363 @default.
- W4383483598 cites W3038767246 @default.
- W4383483598 cites W3048309423 @default.
- W4383483598 cites W3084164037 @default.
- W4383483598 cites W3105194426 @default.
- W4383483598 cites W3137488217 @default.
- W4383483598 cites W3146935595 @default.
- W4383483598 cites W4302010920 @default.
- W4383483598 doi "https://doi.org/10.1016/j.heliyon.2023.e17119" @default.
- W4383483598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37539320" @default.
- W4383483598 hasPublicationYear "2023" @default.
- W4383483598 type Work @default.
- W4383483598 citedByCount "0" @default.
- W4383483598 crossrefType "journal-article" @default.
- W4383483598 hasAuthorship W4383483598A5006541554 @default.
- W4383483598 hasAuthorship W4383483598A5011219441 @default.
- W4383483598 hasAuthorship W4383483598A5015027082 @default.
- W4383483598 hasAuthorship W4383483598A5016173294 @default.
- W4383483598 hasAuthorship W4383483598A5030182006 @default.
- W4383483598 hasAuthorship W4383483598A5034994816 @default.
- W4383483598 hasAuthorship W4383483598A5067221645 @default.
- W4383483598 hasAuthorship W4383483598A5076961188 @default.
- W4383483598 hasAuthorship W4383483598A5079700843 @default.
- W4383483598 hasAuthorship W4383483598A5080990304 @default.
- W4383483598 hasBestOaLocation W43834835981 @default.
- W4383483598 hasConcept C121608353 @default.
- W4383483598 hasConcept C167672396 @default.
- W4383483598 hasConcept C203014093 @default.