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• W4383896403 abstract "Introduction: HIV-associated mortality after a central nervous system opportunistic infection can reach up to 78%. In populations with limited economic resources, few studies have evaluated the clinical outcomes of these infections in patients with HIV. Methods: We performed an observational analytical study using our hospital's database. Sociodemographic, clinical, and paraclinical data were gathered from patients with HIV-associated opportunistic neurological infections attended between January 2019 and January 2021. The aim of the study was to describe the in-hospital mortality rate and to establish associations with sociodemographic, clinical, and paraclinical variables. Results: Seventy-five patients were included, with a mean age of 38.7 years. Fourteen (31.8%) were receiving antiretroviral therapy at the time of admission. The most frequent neurological infections were cerebral toxoplasmosis (37.3%, n = 28), meningeal cryptococcosis (20%, n = 15), and neurosyphilis (20%, n = 15). The in-hospital mortality rate was 25.3% (n = 19). The variables associated with increased mortality risk were diagnóstico of meningeal cryptococcosis, admission to the ICU, and presence of fever. The variables associated with decreased mortality risk were CSF/blood glucose ratio > 0.5 and normal body mass index (18–25). Conclusions: In a population of patients with HIV-associated opportunistic neurological infections, in-hospital mortality was 25.3%. The diagnóstico of meningeal cryptococcosis, admission to the ICU, and the presence of fever are associated with higher mortality risk. To the contrary, CSF/blood glucose ratio > 0.5 and normal body mass index are associated with lower mortality risk. Introducción: La mortalidad asociada al VIH luego de una infección oportunista del SNC puede ser hasta del 78%. En poblaciones de bajos recursos económicos, existen pocos estudios que evalúen el desenlace clínico de estas infecciones en pacientes con VIH. Metodología: Estudio observacional analítico usando la base de datos del hospital base de los investigadores. Se extrajeron datos sociodemográficos, clínicos y paraclínicos de los pacientes con neuroinfecciones oportunistas asociadas a VIH, entre enero del 2019 y enero del 2021. Se busca describir la mortalidad al final de la hospitalización y establecer asociaciones con las variables sociodemográficas, clínicas y paraclínicas. Resultados: Se incluyeron 75 pacientes. La edad media fue 38.7 años. El 31.8% (n = 14) estaba recibiendo terapia anti-retroviral al momento del ingreso. Las neuroinfecciones más frecuentes fueron toxoplasmosis cerebral (37.3%, n = 28), criptococosis meníngea (20%, n = 15) y neurosífilis (20%, n = 15). La mortalidad al final de la hospitalización fue de 25.3% (n = 19). Las variables asociadas con aumento en la mortalidad fueron: diagnóstico de criptococosis meníngea, ingreso a UCI y presencia de fiebre. Las variables asociadas con disminución del riesgo de mortalidad fueron: relación de glucorraquia/glucemia mayor de 0.5 e IMC normal (18–25). Conclusiones: En una población de pacientes con neuroinfección oportunista asociada a VIH, la mortalidad al final de la hospitalización fue de 25.3%. El diagnóstico de criptococosis meníngea, el ingreso a UCI y la presencia de fiebre, están asociadas con mayor riesgo de mortalidad. Por el contrario, una relación glucorraquia/glucemia mayor de 0.5 y un IMC normal están asociados con un menor riesgo de mortalidad." @default.
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• W4383896403 date "2023-07-01" @default.
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• W4383896403 title "Characterisation and variables associated with mortality in a population with HIV and central nervous system opportunistic infections in a Colombian public hospital in Bogotá" @default.
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• W4383896403 doi "https://doi.org/10.1016/j.neurop.2023.100127" @default.
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