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- W4384037787 endingPage "107309" @default.
- W4384037787 startingPage "107309" @default.
- W4384037787 abstract "Studies in zebrafish can unravel the functions of cellular communication and thus identify novel bench-to-bedside drugs targeting cellular communication signaling molecules. Due to the incomplete annotation of zebrafish proteome, the knowledge of zebrafish receptors, ligands, and tools to explore their interactome is limited. To address this gap, we de novo predicted the cellular localization of zebrafish reference proteome using deep learning algorithm. We combined the predicted and existing annotations on cellular localization of zebrafish proteins and created repositories of zebrafish ligands, membrane receptome, and interactome as well as associated diseases and targeting drugs. Unlike other tools, our interactome atlas is based on both the physical interaction data of zebrafish proteome and existing human ligand-receptor pair databases. The resources are available as R and Python scripts. DanioTalk provides a novel resource for researchers interested in targeting cellular communication in zebrafish, as we demonstrate in applications studying synapse and axo-glial interactome. DanioTalk methodology can be applied to build and explore the ligand-receptor atlas of other non-mammalian model organisms." @default.
- W4384037787 created "2023-07-13" @default.
- W4384037787 creator A5009127440 @default.
- W4384037787 creator A5020737959 @default.
- W4384037787 creator A5052786144 @default.
- W4384037787 date "2023-08-01" @default.
- W4384037787 modified "2023-10-05" @default.
- W4384037787 title "A ligand-receptor interactome atlas of the zebrafish" @default.
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