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- W4384338671 abstract "Purpose: There are limited data on the prevalence and genetic diversity of herpes simplex virus type 1 (HSV-1) virulence genes in ocular isolates. Here, we sequenced 36 HSV-1 ocular isolates, collected by the Bascom Palmer Eye Institute, a university-based eye hospital, from three different ocular anatomical sites (conjunctiva, cornea, and eyelid) and carried out a genomic and phylogenetic analyses. Methods: The PacBio Sequel II long read platform was used for genome sequencing. Phylogenetic analysis and genomic analysis were performed to help better understand genetic variability among common virulence genes in ocular herpetic disease. Results: A phylogenetic network generated using the genome sequences of the 36 Bascom Palmer ocular isolates, plus 174 additional strains showed that ocular isolates do not group together phylogenetically. Analysis of the thymidine kinase and DNA polymerase protein sequences from the Bascom Palmer isolates showed multiple novel single nucleotide polymorphisms, but only one, BP-K14 encoded a known thymidine kinase acyclovir resistance mutation. An analysis of the multiple sequence alignment comprising the 51 total ocular isolates versus 159 nonocular strains detected several possible single nucleotide polymorphisms in HSV-1 genes that were found significantly more often in the ocular isolates. These genes included UL6, gM, VP19c, VHS, gC, VP11/12, and gG. Conclusions: There does not seem to be a specific genetic feature of viruses causing ocular infection. The identification of novel and common recurrent polymorphisms may help to understand the drivers of herpetic pathogenicity and specific factors that may influence the virulence of ocular disease." @default.
- W4384338671 created "2023-07-15" @default.
- W4384338671 creator A5017258915 @default.
- W4384338671 creator A5039648429 @default.
- W4384338671 creator A5071889184 @default.
- W4384338671 creator A5082646052 @default.
- W4384338671 creator A5088453479 @default.
- W4384338671 date "2023-07-14" @default.
- W4384338671 modified "2023-10-14" @default.
- W4384338671 title "Phylogenetic and Genomic Characterization of Whole Genome Sequences of Ocular Herpes Simplex Virus Type 1 Isolates Identifies Possible Virulence Determinants in Humans" @default.
- W4384338671 cites W153924788 @default.
- W4384338671 cites W1540321365 @default.
- W4384338671 cites W1573378471 @default.
- W4384338671 cites W1749249600 @default.
- W4384338671 cites W1880845650 @default.
- W4384338671 cites W1946913530 @default.
- W4384338671 cites W1966390821 @default.
- W4384338671 cites W1974567509 @default.
- W4384338671 cites W1975556749 @default.
- W4384338671 cites W1985874150 @default.
- W4384338671 cites W1988109653 @default.
- W4384338671 cites W1995305578 @default.
- W4384338671 cites W1996828685 @default.
- W4384338671 cites W2003596982 @default.
- W4384338671 cites W2006659101 @default.
- W4384338671 cites W2008058658 @default.
- W4384338671 cites W2008245319 @default.
- W4384338671 cites W2011916802 @default.
- W4384338671 cites W2012373229 @default.
- W4384338671 cites W2013243191 @default.
- W4384338671 cites W2021067115 @default.
- W4384338671 cites W2039914282 @default.
- W4384338671 cites W2040998815 @default.
- W4384338671 cites W2045378555 @default.
- W4384338671 cites W2046097509 @default.
- W4384338671 cites W2046575349 @default.
- W4384338671 cites W2046801142 @default.
- W4384338671 cites W2053681932 @default.
- W4384338671 cites W2055298722 @default.
- W4384338671 cites W2055679870 @default.
- W4384338671 cites W2056398804 @default.
- W4384338671 cites W2059686897 @default.
- W4384338671 cites W2060467532 @default.
- W4384338671 cites W2062520454 @default.
- W4384338671 cites W2063562604 @default.
- W4384338671 cites W2076267683 @default.
- W4384338671 cites W2081238241 @default.
- W4384338671 cites W2082959860 @default.
- W4384338671 cites W2084603524 @default.
- W4384338671 cites W2093700540 @default.
- W4384338671 cites W2094420164 @default.
- W4384338671 cites W2099152918 @default.
- W4384338671 cites W2102142750 @default.
- W4384338671 cites W2107149965 @default.
- W4384338671 cites W2117212078 @default.
- W4384338671 cites W2129382212 @default.
- W4384338671 cites W2132461070 @default.
- W4384338671 cites W2135092184 @default.
- W4384338671 cites W2140872922 @default.
- W4384338671 cites W2143613296 @default.
- W4384338671 cites W2144064375 @default.
- W4384338671 cites W2144423642 @default.
- W4384338671 cites W2145846309 @default.
- W4384338671 cites W2152207030 @default.
- W4384338671 cites W2152700794 @default.
- W4384338671 cites W2156681405 @default.
- W4384338671 cites W2160088199 @default.
- W4384338671 cites W2160378127 @default.
- W4384338671 cites W2163000811 @default.
- W4384338671 cites W2164320786 @default.
- W4384338671 cites W2171126517 @default.
- W4384338671 cites W2264050698 @default.
- W4384338671 cites W2296214831 @default.
- W4384338671 cites W2297786532 @default.
- W4384338671 cites W2310510931 @default.
- W4384338671 cites W2311203695 @default.
- W4384338671 cites W2323396504 @default.
- W4384338671 cites W2471468622 @default.
- W4384338671 cites W2555890244 @default.
- W4384338671 cites W2596705354 @default.
- W4384338671 cites W2609620339 @default.
- W4384338671 cites W2614081736 @default.
- W4384338671 cites W2742683883 @default.
- W4384338671 cites W2755331695 @default.
- W4384338671 cites W2786216235 @default.
- W4384338671 cites W2803892206 @default.
- W4384338671 cites W2914089241 @default.
- W4384338671 cites W2946416264 @default.
- W4384338671 cites W2950210117 @default.
- W4384338671 cites W2965314874 @default.
- W4384338671 cites W2973784404 @default.
- W4384338671 cites W3022275668 @default.
- W4384338671 cites W3024471762 @default.
- W4384338671 cites W3045642333 @default.
- W4384338671 cites W3110778414 @default.
- W4384338671 cites W3128198169 @default.
- W4384338671 cites W3131452161 @default.
- W4384338671 cites W3166872497 @default.