Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385186269> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4385186269 endingPage "231" @default.
- W4385186269 startingPage "231" @default.
- W4385186269 abstract "Modern anticancer research has employed advanced computational techniques and artificial intelligence methods for drug discovery and development, along with the massive amount of generated clinical and in silico data over the last decades. Diverse computational techniques and state-of-the-art algorithms are being developed to enhance traditional Rational Drug Design pipelines and achieve cost-efficient and successful anticancer candidates to promote human health. Towards this direction, we have developed a pharmacophore- based drug design approach against MCT4, a member of the monocarboxylate transporter family (MCT), which is the main carrier of lactate across the membrane and highly involved in cancer cell metabolism. Specifically, MCT4 is a promising target for therapeutic strategies as it overexpresses in glycolytic tumors, and its inhibition has shown promising anticancer effects. Due to the lack of experimentally determined structure, we have elucidated the key features of the protein through an in silico drug design strategy, including for molecular modelling, molecular dynamics, and pharmacophore elucidation, towards the identification of specific inhibitors as a novel anti-cancer strategy." @default.
- W4385186269 created "2023-07-25" @default.
- W4385186269 creator A5029580586 @default.
- W4385186269 creator A5036815066 @default.
- W4385186269 creator A5045881903 @default.
- W4385186269 creator A5059993695 @default.
- W4385186269 creator A5079421874 @default.
- W4385186269 date "2023-01-01" @default.
- W4385186269 modified "2023-09-24" @default.
- W4385186269 title "Computational Methods for Anticancer Drug Discovery; The MCT4 Paradigm" @default.
- W4385186269 doi "https://doi.org/10.1007/978-3-031-31982-2_25" @default.
- W4385186269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37486498" @default.
- W4385186269 hasPublicationYear "2023" @default.
- W4385186269 type Work @default.
- W4385186269 citedByCount "0" @default.
- W4385186269 crossrefType "book-chapter" @default.
- W4385186269 hasAuthorship W4385186269A5029580586 @default.
- W4385186269 hasAuthorship W4385186269A5036815066 @default.
- W4385186269 hasAuthorship W4385186269A5045881903 @default.
- W4385186269 hasAuthorship W4385186269A5059993695 @default.
- W4385186269 hasAuthorship W4385186269A5079421874 @default.
- W4385186269 hasConcept C104317684 @default.
- W4385186269 hasConcept C185592680 @default.
- W4385186269 hasConcept C2775905019 @default.
- W4385186269 hasConcept C2780035454 @default.
- W4385186269 hasConcept C41008148 @default.
- W4385186269 hasConcept C55493867 @default.
- W4385186269 hasConcept C56173144 @default.
- W4385186269 hasConcept C60644358 @default.
- W4385186269 hasConcept C70721500 @default.
- W4385186269 hasConcept C74187038 @default.
- W4385186269 hasConcept C86803240 @default.
- W4385186269 hasConcept C98274493 @default.
- W4385186269 hasConceptScore W4385186269C104317684 @default.
- W4385186269 hasConceptScore W4385186269C185592680 @default.
- W4385186269 hasConceptScore W4385186269C2775905019 @default.
- W4385186269 hasConceptScore W4385186269C2780035454 @default.
- W4385186269 hasConceptScore W4385186269C41008148 @default.
- W4385186269 hasConceptScore W4385186269C55493867 @default.
- W4385186269 hasConceptScore W4385186269C56173144 @default.
- W4385186269 hasConceptScore W4385186269C60644358 @default.
- W4385186269 hasConceptScore W4385186269C70721500 @default.
- W4385186269 hasConceptScore W4385186269C74187038 @default.
- W4385186269 hasConceptScore W4385186269C86803240 @default.
- W4385186269 hasConceptScore W4385186269C98274493 @default.
- W4385186269 hasLocation W43851862691 @default.
- W4385186269 hasLocation W43851862692 @default.
- W4385186269 hasOpenAccess W4385186269 @default.
- W4385186269 hasPrimaryLocation W43851862691 @default.
- W4385186269 hasRelatedWork W1984352342 @default.
- W4385186269 hasRelatedWork W2024311391 @default.
- W4385186269 hasRelatedWork W2061397990 @default.
- W4385186269 hasRelatedWork W2084622760 @default.
- W4385186269 hasRelatedWork W2640842492 @default.
- W4385186269 hasRelatedWork W2742986615 @default.
- W4385186269 hasRelatedWork W2888254826 @default.
- W4385186269 hasRelatedWork W3047027651 @default.
- W4385186269 hasRelatedWork W4303198934 @default.
- W4385186269 hasRelatedWork W4362507064 @default.
- W4385186269 isParatext "false" @default.
- W4385186269 isRetracted "false" @default.
- W4385186269 workType "book-chapter" @default.