Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386074846> ?p ?o ?g. }
- W4386074846 abstract "Patients with chronic kidney disease (CKD) have reduced expression of erythroid nuclear factor-related factor 2 (NRF2) and increased nuclear factor κB (NF-κB). Food as medicine has been proposed as an adjuvant therapeutic alternative in modulating these factors. No studies have investigated the effects of sulforaphane (SFN) in cruciferous vegetables on the expression of these genes in patients with CKD.The study aimed to evaluate the effects of SFN on the expression of NRF2 and NF-κB in patients on hemodialysis (HD).A randomized, double-blind, crossover study was performed on 30 patients on regular HD. Fourteen patients were randomly allocated to the intervention group (1 sachet/day of 2.5 g containing 1% SFN extract with 0.5% myrosinase) and 16 patients to the placebo group (1 sachet/day of 2.5 g containing corn starch colored with chlorophyll) for 2 months. After a washout period of 2 months, the groups were switched. NRF2 and NF-κB mRNA expression was evaluated by real-time quantitative polymerase chain reaction, and tumor necrosis factor alpha and interleukin-6 levels were quantified by enzyme-linked immunosorbent assay. Malondialdehyde was evaluated as a marker of lipid peroxidation.Twenty-five patients (17 women, 55 [interquartile range = 19] years and 55 [interquartile range = 74] months on HD) completed the study. There was no significant difference concerning the expression of mRNA NRF2 (P = .915) and mRNA NF-κB (P = .806) after supplementation with SFN. There was no difference in pro-inflammatory and oxidative stress biomarkers.150 μmol of SFN for 2 months had no antioxidant and anti-inflammatory effect in patients with CKD undergoing HD." @default.
- W4386074846 created "2023-08-23" @default.
- W4386074846 creator A5001224623 @default.
- W4386074846 creator A5005480103 @default.
- W4386074846 creator A5022024653 @default.
- W4386074846 creator A5022091044 @default.
- W4386074846 creator A5036474175 @default.
- W4386074846 creator A5045817626 @default.
- W4386074846 creator A5046705634 @default.
- W4386074846 creator A5052612282 @default.
- W4386074846 creator A5073859962 @default.
- W4386074846 creator A5084533818 @default.
- W4386074846 creator A5092676253 @default.
- W4386074846 creator A5022554718 @default.
- W4386074846 date "2023-08-01" @default.
- W4386074846 modified "2023-10-09" @default.
- W4386074846 title "Sulforaphane supplementation did not modulate NRF2 and NF-kB mRNA expressions in hemodialysis patients" @default.
- W4386074846 cites W1683287975 @default.
- W4386074846 cites W1775232482 @default.
- W4386074846 cites W1789479632 @default.
- W4386074846 cites W1983310681 @default.
- W4386074846 cites W1991201692 @default.
- W4386074846 cites W2022539296 @default.
- W4386074846 cites W2022546275 @default.
- W4386074846 cites W2026212248 @default.
- W4386074846 cites W2034614258 @default.
- W4386074846 cites W2040034826 @default.
- W4386074846 cites W2063387461 @default.
- W4386074846 cites W2065899762 @default.
- W4386074846 cites W2075685041 @default.
- W4386074846 cites W2085203929 @default.
- W4386074846 cites W2107277218 @default.
- W4386074846 cites W2164209307 @default.
- W4386074846 cites W2328967496 @default.
- W4386074846 cites W2462073489 @default.
- W4386074846 cites W2549382977 @default.
- W4386074846 cites W2589064393 @default.
- W4386074846 cites W2612297599 @default.
- W4386074846 cites W2766209227 @default.
- W4386074846 cites W2790931380 @default.
- W4386074846 cites W2799986334 @default.
- W4386074846 cites W2890985556 @default.
- W4386074846 cites W2899111175 @default.
- W4386074846 cites W2927586557 @default.
- W4386074846 cites W2953745936 @default.
- W4386074846 cites W2966372139 @default.
- W4386074846 cites W2970148165 @default.
- W4386074846 cites W2980741583 @default.
- W4386074846 cites W3005957464 @default.
- W4386074846 cites W3014473638 @default.
- W4386074846 cites W3022705315 @default.
- W4386074846 cites W3022724034 @default.
- W4386074846 cites W3088426205 @default.
- W4386074846 cites W3115077728 @default.
- W4386074846 cites W3196574919 @default.
- W4386074846 cites W4220748657 @default.
- W4386074846 cites W4294989725 @default.
- W4386074846 doi "https://doi.org/10.1053/j.jrn.2023.08.008" @default.
- W4386074846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37619675" @default.
- W4386074846 hasPublicationYear "2023" @default.
- W4386074846 type Work @default.
- W4386074846 citedByCount "0" @default.
- W4386074846 crossrefType "journal-article" @default.
- W4386074846 hasAuthorship W4386074846A5001224623 @default.
- W4386074846 hasAuthorship W4386074846A5005480103 @default.
- W4386074846 hasAuthorship W4386074846A5022024653 @default.
- W4386074846 hasAuthorship W4386074846A5022091044 @default.
- W4386074846 hasAuthorship W4386074846A5022554718 @default.
- W4386074846 hasAuthorship W4386074846A5036474175 @default.
- W4386074846 hasAuthorship W4386074846A5045817626 @default.
- W4386074846 hasAuthorship W4386074846A5046705634 @default.
- W4386074846 hasAuthorship W4386074846A5052612282 @default.
- W4386074846 hasAuthorship W4386074846A5073859962 @default.
- W4386074846 hasAuthorship W4386074846A5084533818 @default.
- W4386074846 hasAuthorship W4386074846A5092676253 @default.
- W4386074846 hasConcept C119060515 @default.
- W4386074846 hasConcept C126322002 @default.
- W4386074846 hasConcept C134018914 @default.
- W4386074846 hasConcept C142724271 @default.
- W4386074846 hasConcept C164027704 @default.
- W4386074846 hasConcept C204787440 @default.
- W4386074846 hasConcept C27081682 @default.
- W4386074846 hasConcept C2776151105 @default.
- W4386074846 hasConcept C2776914184 @default.
- W4386074846 hasConcept C2778063415 @default.
- W4386074846 hasConcept C2778401633 @default.
- W4386074846 hasConcept C2778653478 @default.
- W4386074846 hasConcept C2780841255 @default.
- W4386074846 hasConcept C502942594 @default.
- W4386074846 hasConcept C71924100 @default.
- W4386074846 hasConcept C87813604 @default.
- W4386074846 hasConcept C90924648 @default.
- W4386074846 hasConceptScore W4386074846C119060515 @default.
- W4386074846 hasConceptScore W4386074846C126322002 @default.
- W4386074846 hasConceptScore W4386074846C134018914 @default.
- W4386074846 hasConceptScore W4386074846C142724271 @default.
- W4386074846 hasConceptScore W4386074846C164027704 @default.
- W4386074846 hasConceptScore W4386074846C204787440 @default.
- W4386074846 hasConceptScore W4386074846C27081682 @default.
- W4386074846 hasConceptScore W4386074846C2776151105 @default.