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• W4386407514 abstract "Objective: To explore the association of different obesity measurement indexes on serum C-reactive protein (CRP) in Chinese adult women. Methods: The data were obtained from baseline and follow-up surveys of the urban Breast Cancer Screening Program in Shuangliu District, Chengdu. A total of 441 adult women were included in the study. A questionnaire survey, physical examination, and laboratory testing were conducted on the subjects. Multivariate logistic regression model, two-level mixed effects logistic regression model, and restricted cubic spline method were used to investigate the linear and nonlinear correlation between different obesity measurement indexes and serum CRP in adult women. Results: For every 1 unit increase in BMI, waist circumference (WC), and adiposity, the risk of elevated serum CRP or exacerbation of chronic low-grade inflammation in adult women increased by 16.5%, 5.0%, and 11.1% (P<0.05), respectively. Both BMI and adiposity were nonlinear correlated with serum CRP. Using BMI=24.0 kg/m2 as the reference point, serum CRP level increased with the increase of BMI when BMI >24.0 kg/m2. Using adiposity=30% as the reference point, serum CRP level increased with the increase of adiposity when adiposity >30%. Conclusions: Overall, obesity reflected by BMI had the strongest association with serum CRP in adult women, followed by body fat content reflected by adiposity, and central obesity reflected by WC had the weakest association with CRP. Adult women with BMI >24.0 kg/m2 or adiposity >30% are at high risk for obesity-related inflammatory manifestations.目的： 探讨不同的肥胖测量指标对中国成年女性血清C反应蛋白（CRP）的关联。 方法： 数据来源于成都市双流区城镇乳腺癌筛查项目基线调查及随访调查，共纳入441名成年女性。对研究对象开展问卷调查、体格检查和实验室检测。采用多因素logistic回归模型、两水平线性混合效应模型和限制性立方样条模型探讨不同肥胖测量指标与成年女性血清CRP的线性和非线性关联。 结果： BMI、腰围和体脂率每增加1个单位，成年女性血清CRP升高即慢性低度炎症状态加重的风险分别增加16.5%、5.0%和11.1%（P<0.05）。BMI和体脂率与血清CRP之间存在非线性关联，以BMI=24.0 kg/m2为参考点，当BMI>24.0 kg/m2时，血清CRP水平随BMI的增加而增加；以体脂率=30%为参考点，当体脂率>30%时，血清CRP水平随体脂率的增加而增加。 结论： BMI反映的整体肥胖与成年女性血清CRP关联最强，体脂率反映的体脂含量与血清CRP关联强度次之，腰围反映的中心性肥胖与血清CRP关联相对最弱。BMI>24.0 kg/m2和体脂率>30%的成年女性是产生肥胖相关炎性表现的高危险人群。." @default.
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• W4386407514 date "2023-08-10" @default.
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• W4386407514 title "[Association between different obesity measurement indexes and serum C-reactive protein in adult women]." @default.
• W4386407514 doi "https://doi.org/10.3760/cma.j.cn112338-20221122-00992" @default.
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