Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386710808> ?p ?o ?g. }
- W4386710808 abstract "The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV that is effective at minimal doses in a lethal mouse model of infection. We structurally analyze and characterize the binding mode of a prototypical potent Gn domain-A-binding antibody that blocks attachment and of an antibody that inhibits infection by abrogating the fusion process as previously determined. Surprisingly, the Gn domain-A antibody does not directly block RVFV Gn interaction with the host receptor low density lipoprotein receptor-related protein 1 (LRP1) as determined by a competitive assay. This study identifies a rationally designed combination of human mAbs deserving of future investigation for use in humans against RVFV infection. Using a two-pronged mechanistic approach, we demonstrate the potent efficacy of a rationally designed combination mAb therapeutic." @default.
- W4386710808 created "2023-09-14" @default.
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- W4386710808 date "2023-09-13" @default.
- W4386710808 modified "2023-09-29" @default.
- W4386710808 title "Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses" @default.
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- W4386710808 doi "https://doi.org/10.1038/s41467-023-41171-3" @default.
- W4386710808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37704627" @default.
- W4386710808 hasPublicationYear "2023" @default.
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