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- W4946853 abstract "This chapter discusses the design and synthesis of influenza virus sialidase inhibitors as potential anti-influenza drugs. The influenza virus sialidase appears to be important in the replication cycle of the virus and plays a number of important roles. One of these roles appears to be in the facilitation of virus movement through the respiratory tract mucus. The influenza virus sialidase is a tetrameric glycoprotein with a subunit molecular weight of 60 kDa. The enzyme acts as a glycohydrolase cleaving α-ketosidically linked terminal N-acetyl-D-neuraminic acid (Neu5Ac) residues on the mucosal sialoglycoproteins, thus reducing the mucus viscosity and concomitantly reducing the concentration of highly sialylated mucosal secretions which may otherwise significantly slow the virus and inhibit its reaction to an infection. As a result of the enzyme's action, viral penetration to the target epithelial cells is enhanced. Another role that has been associated with this viral enzyme is its capacity to assist in the release of the newly synthesized virions from the infected cells. The inhibition of the sialidase action may permit the immune system time to mount an appropriate response to the newly synthesized progeny, which are clumped at the infected cell's surface before they are released." @default.
- W4946853 created "2016-06-24" @default.
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- W4946853 date "1999-01-01" @default.
- W4946853 modified "2023-09-23" @default.
- W4946853 title "Sialidase inhibitors as anti-influenza drugs" @default.
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- W4946853 doi "https://doi.org/10.1016/s1075-8593(99)80006-9" @default.
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