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- W52471159 abstract "Publisher Summary Hydrazine and its derivatives are used in industry and medicine because of their chemical reactivity. These compounds have also been shown to be toxic and/or carcinogenic agents. This chapter describes the biochemical nature of a cytochrome P-450 spectral intermediate when any of a number of 1, 1–disubstituted hydrazines were added to suspensions of rat liver microsomes in the presence of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and oxygen. The chapter provides evidence that the complex is abortive in nature and, thus, the complexed cytochrome P-450 can no longer function in its role as a terminal oxidase. In the presence of NADPH and oxygen, the 1, 1–disubstituted hydrazines were metabolized to products that form a spectral intermediate with cytochrome P-450. The metabolite stabilized cytochrome P-450 in the ferric state because reduction to a ferrous state was only seen under anaerobic conditions and was reversed by the re-addition of oxygen. Studies with known substrates and/or inhibitors of cytochrome P-450 and induction experiments suggest that complex formation was dependent on metabolism by the phenobarbital-induced form of cytochrome P-450." @default.
- W52471159 created "2016-06-24" @default.
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- W52471159 date "1980-01-01" @default.
- W52471159 modified "2023-10-18" @default.
- W52471159 title "EVIDENCE FOR INHIBITORY COMPLEXES FORMED WITH CYTOCHROME P-450 AND A METABOLITE OF 1,1-DISUBSTITUTED HYDRAZINES" @default.
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- W52471159 doi "https://doi.org/10.1016/b978-0-12-187702-6.50117-1" @default.
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