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- W53646112 abstract "SUMMARY After 24 hours of fasting female Wistar rats were immobilized for 24 hours. The effect of different Prostaglandins was investigated on the development of gastric ulcers. The following Prostaglandins were used: PG-E1; PG-E2; 16-16-dimethyl-PG-E2; 6-keto-PG-F1 α PG-F2 alpha and PG-I2 /Prostacycline/. All Prostaglandins were tested in 100 /μ/kg dose, given either intraperitoneally or orally in the 0. 6th, 12th and 18th hour of immobilization. It was established that in the case of i.p. administration : 1./ the most effective analogues were the PG-E2 and the 16-16-dimethyl-PG-E2; 2./ the PG-F2 alpha and the PG-I2 had no significant effect; 3./ in the case of a short treatment the PG-E1 enhanced, while after a longer treatment it decreased the number of gastric ulcers; 4./ the 6-keto-PG-F1 alpha had a significant ulcerogenic effect. In the case of oral treatment : 1./ the most effective analogue was the PG-I2; 2./ with the exception of 6-keto-PG-F1 alpha all Prostaglandins showed an anti-ulcer effect in different degrees; 3./ the 16-16-dimethyl-PG-E2 analogue had a strong diarrhoea-inducing effect; 4./ the 6-keto-PG-F1 alpha analogue had a significant ulcerogenic effect." @default.
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- W53646112 date "1981-01-01" @default.
- W53646112 modified "2023-09-27" @default.
- W53646112 title "THE EFFECT OF DIFFERENT PROSTAGLANDINS ON RESTRAIN ULCER OF RAT" @default.
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- W53646112 doi "https://doi.org/10.1016/b978-0-08-027350-1.50021-9" @default.
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