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- W63575320 abstract "Transforming growth factor-βs (TGF-βs) belong to a superfamily of related peptides that play pivotal roles in intercellular communication. Among these biological agents, TGF-β1 has been involved in a number of brain functions and dysfunctions throughout life, ranging from neurogenesis to neurodegeneration. Animal models mimicking some aspects of human brain pathologies have led to the idea that TGF-β may be a good therapeutic candidate. For instance, TGF-β protects neurons against brain attack, while regulating the catabolism of the amyloid-β peptide during Alzheimer’s disease. Excitotoxicity and apoptosis are the hallmarks of neuronal death in a number of brain disorders. TGF-β1 was found strongly upregulated in the central nervous system following excitotoxic brain damages and is thought to serve a protective endogenous response of the brain. A proposed mechanism is that TGF-β1 protects neurons against excitotoxicity by inhibiting tissue-type plasminogen activator-mediated potentiation of glutamatergic NMDA receptor activity, thanks to the upregulation of the type 1 plasminogen activator inhibitor in astrocytes. In addition, TGF-β1 also acts as an antiapoptotic factor for neurons, probably through the activation of the extracellular signal-regulated kinase 1/2, NF-kappa-B, and/or the recruitment of the antiapoptotic protein Bad. Though a full knowledge of the multiple mechanisms of action involved is required, it thus appears that targeting TGF-β1 for therapeutic purposes in brain pathologies might be valuable." @default.
- W63575320 created "2016-06-24" @default.
- W63575320 creator A5004749164 @default.
- W63575320 creator A5015421764 @default.
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- W63575320 date "2008-01-01" @default.
- W63575320 modified "2023-09-27" @default.
- W63575320 title "Transforming Growth Factor-β in Brain Functions and Dysfunctions" @default.
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