Matches in SemOpenAlex for { <https://semopenalex.org/work/W753551710> ?p ?o ?g. }
- W753551710 endingPage "683" @default.
- W753551710 startingPage "671" @default.
- W753551710 abstract "A significant proportion of total circulating growth hormone (GH) is bound to a high affinity growth hormone binding protein (GHBP). Several low affinity binding proteins have also been described. Significant differences between species exist with respect to origin and regulation of GHBP, but generally it resembles the extracellular domain of the GH receptor. Concentrations are associated with GH status, body composition and other factors. Although the clinical relevance of GHBP is not fully understood it is suggested that concentrations indirectly reflect GH receptor status. This is supported by cases of Laron's syndrome where a molecular defect in the extracellular domain of the GH receptor is associated with low or unmeasurable GHBP concentrations. Methods to measure GHBP have evolved from chromatographic, activity based procedures to direct immunoassays. In clinical practice, measurement of GHBP can be helpful to differentiate between GH deficiency and GH insensitivity, particularly if GHBP is absent." @default.
- W753551710 created "2016-06-24" @default.
- W753551710 creator A5057394610 @default.
- W753551710 creator A5086348286 @default.
- W753551710 date "2015-10-01" @default.
- W753551710 modified "2023-09-27" @default.
- W753551710 title "Growth hormone binding protein – Physiological and analytical aspects" @default.
- W753551710 cites W1501554319 @default.
- W753551710 cites W1695174616 @default.
- W753551710 cites W1964916243 @default.
- W753551710 cites W1966341815 @default.
- W753551710 cites W1969570257 @default.
- W753551710 cites W1969917278 @default.
- W753551710 cites W1971123863 @default.
- W753551710 cites W1971792335 @default.
- W753551710 cites W1974312903 @default.
- W753551710 cites W1975565910 @default.
- W753551710 cites W1975680180 @default.
- W753551710 cites W1976843101 @default.
- W753551710 cites W1978090276 @default.
- W753551710 cites W1980739132 @default.
- W753551710 cites W1981476147 @default.
- W753551710 cites W1981853641 @default.
- W753551710 cites W1981880837 @default.
- W753551710 cites W1983031526 @default.
- W753551710 cites W1984828633 @default.
- W753551710 cites W1985509812 @default.
- W753551710 cites W1985594739 @default.
- W753551710 cites W1985621366 @default.
- W753551710 cites W1986384675 @default.
- W753551710 cites W1986739790 @default.
- W753551710 cites W1986794036 @default.
- W753551710 cites W1987924658 @default.
- W753551710 cites W1988236032 @default.
- W753551710 cites W1990788363 @default.
- W753551710 cites W1993776398 @default.
- W753551710 cites W1994843527 @default.
- W753551710 cites W1996757852 @default.
- W753551710 cites W1997522702 @default.
- W753551710 cites W1999218185 @default.
- W753551710 cites W1999547234 @default.
- W753551710 cites W1999875534 @default.
- W753551710 cites W2000669753 @default.
- W753551710 cites W2001888314 @default.
- W753551710 cites W2002930594 @default.
- W753551710 cites W2006827179 @default.
- W753551710 cites W2009880957 @default.
- W753551710 cites W2012711566 @default.
- W753551710 cites W2015004430 @default.
- W753551710 cites W2018200926 @default.
- W753551710 cites W2018292361 @default.
- W753551710 cites W2020429800 @default.
- W753551710 cites W2021365471 @default.
- W753551710 cites W2021914226 @default.
- W753551710 cites W2023241031 @default.
- W753551710 cites W2023611038 @default.
- W753551710 cites W2024054676 @default.
- W753551710 cites W2025019711 @default.
- W753551710 cites W2025974332 @default.
- W753551710 cites W2026230914 @default.
- W753551710 cites W2026936135 @default.
- W753551710 cites W2027062663 @default.
- W753551710 cites W2027937382 @default.
- W753551710 cites W2029285727 @default.
- W753551710 cites W2030789027 @default.
- W753551710 cites W2031739105 @default.
- W753551710 cites W2032638961 @default.
- W753551710 cites W2034118539 @default.
- W753551710 cites W2035488392 @default.
- W753551710 cites W2036846868 @default.
- W753551710 cites W2037053329 @default.
- W753551710 cites W2037226702 @default.
- W753551710 cites W2042389086 @default.
- W753551710 cites W2042574132 @default.
- W753551710 cites W2045151759 @default.
- W753551710 cites W2048012100 @default.
- W753551710 cites W2049874783 @default.
- W753551710 cites W2050853712 @default.
- W753551710 cites W2052996645 @default.
- W753551710 cites W2053808640 @default.
- W753551710 cites W2056788640 @default.
- W753551710 cites W2059210791 @default.
- W753551710 cites W2061753579 @default.
- W753551710 cites W2063487518 @default.
- W753551710 cites W2064239723 @default.
- W753551710 cites W2067385360 @default.
- W753551710 cites W2068187158 @default.
- W753551710 cites W2068602127 @default.
- W753551710 cites W2071121751 @default.
- W753551710 cites W2071595515 @default.
- W753551710 cites W2074123389 @default.
- W753551710 cites W2076782099 @default.
- W753551710 cites W2076848886 @default.
- W753551710 cites W2080548920 @default.
- W753551710 cites W2080787688 @default.
- W753551710 cites W2081972160 @default.
- W753551710 cites W2083137480 @default.
- W753551710 cites W2089728262 @default.